Role of Hypoxia in the Interferon Response
In solid tumors, as the tumor grows and the disease progresses, hypoxic regions are often generated, but in contrast to most normal cells which cannot survive under these conditions, tumour cells adapt to hypoxia by HIF-driven mechanisms. Hypoxia can further promote cancer development by generating...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.821816/full |
| _version_ | 1828862464220987392 |
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| author | Esther Arnaiz Esther Arnaiz Adrian L. Harris |
| author_facet | Esther Arnaiz Esther Arnaiz Adrian L. Harris |
| author_sort | Esther Arnaiz |
| collection | DOAJ |
| description | In solid tumors, as the tumor grows and the disease progresses, hypoxic regions are often generated, but in contrast to most normal cells which cannot survive under these conditions, tumour cells adapt to hypoxia by HIF-driven mechanisms. Hypoxia can further promote cancer development by generating an immunosuppressive environment within the tumour mass, which allows tumour cells to escape the immune system recognition. This is achieved by recruiting immunosuppressive cells and by upregulating molecules which block immune cell activation. Hypoxia can also confer resistance to antitumor therapies by inducing the expression of membrane proteins that increase drug efflux or by inhibiting the apoptosis of treated cells. In addition, tumor cells require an active interferon (IFN) signalling pathway for the success of many anticancer therapies, such as radiotherapy or chemotherapy. Therefore, hypoxic effects on this pathway needs to be addressed for a successful treatment. |
| first_indexed | 2024-12-13T03:24:26Z |
| format | Article |
| id | doaj.art-310d2d673f2d4ce4aab721bf23513042 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T03:24:26Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-310d2d673f2d4ce4aab721bf235130422022-12-22T00:01:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-02-011310.3389/fimmu.2022.821816821816Role of Hypoxia in the Interferon ResponseEsther Arnaiz0Esther Arnaiz1Adrian L. Harris2Department of Oncology, University of Oxford, Oxford, United KingdomCambridge Institute for Therapeutic Immunology & Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, United KingdomDepartment of Oncology, University of Oxford, Oxford, United KingdomIn solid tumors, as the tumor grows and the disease progresses, hypoxic regions are often generated, but in contrast to most normal cells which cannot survive under these conditions, tumour cells adapt to hypoxia by HIF-driven mechanisms. Hypoxia can further promote cancer development by generating an immunosuppressive environment within the tumour mass, which allows tumour cells to escape the immune system recognition. This is achieved by recruiting immunosuppressive cells and by upregulating molecules which block immune cell activation. Hypoxia can also confer resistance to antitumor therapies by inducing the expression of membrane proteins that increase drug efflux or by inhibiting the apoptosis of treated cells. In addition, tumor cells require an active interferon (IFN) signalling pathway for the success of many anticancer therapies, such as radiotherapy or chemotherapy. Therefore, hypoxic effects on this pathway needs to be addressed for a successful treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2022.821816/fullhypoxiaIFNcancertherapytype I IFN |
| spellingShingle | Esther Arnaiz Esther Arnaiz Adrian L. Harris Role of Hypoxia in the Interferon Response Frontiers in Immunology hypoxia IFN cancer therapy type I IFN |
| title | Role of Hypoxia in the Interferon Response |
| title_full | Role of Hypoxia in the Interferon Response |
| title_fullStr | Role of Hypoxia in the Interferon Response |
| title_full_unstemmed | Role of Hypoxia in the Interferon Response |
| title_short | Role of Hypoxia in the Interferon Response |
| title_sort | role of hypoxia in the interferon response |
| topic | hypoxia IFN cancer therapy type I IFN |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.821816/full |
| work_keys_str_mv | AT estherarnaiz roleofhypoxiaintheinterferonresponse AT estherarnaiz roleofhypoxiaintheinterferonresponse AT adrianlharris roleofhypoxiaintheinterferonresponse |