A synthetic transcription platform for programmable gene expression in mammalian cells
Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.
Bibliographic Details
| Main Authors: |
William C. W. Chen,
Leonid Gaidukov,
Yong Lai,
Ming-Ru Wu,
Jicong Cao,
Michael J. Gutbrod,
Gigi C. G. Choi,
Rachel P. Utomo,
Ying-Chou Chen,
Liliana Wroblewska,
Manolis Kellis,
Lin Zhang,
Ron Weiss,
Timothy K. Lu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33287-9
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