Clinical implications of co-inhibitory molecule expression in the tumor microenvironment for DC vaccination: a game of stop and go

Clinical implications of co-inhibitory molecule expression in the tumor microenvironment for DC vaccination: a game of stop and go

The aim of therapeutic dendritic cell (DC) vaccines in cancer immunotherapy is to activate cytotoxic T cells to recognize and attack the tumor. T cell activation requires the interaction of the T cell receptor with a cognate major histocompatibility complex (MHC)-peptide complex. Although initiated...

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Bibliographic Details
Main Authors: Angela eVasaturo, Stefania eDi Blasio, Deborah G.A. Peeters, Coco C.H. De Koning, Jolanda eDe Vries, Carl eFigdor, Stanleyson Valentino Hato
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Immunology
Subjects:
Tumor Microenvironment
cancer treatment
checkpoint blockade
DC vaccination
tumor-specific T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00417/full

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