Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types
Abstract Increasing evidence has revealed the large-scale nonstationary synchronizations as traveling waves in spontaneous neural activity. However, the interplay of various cell types in fine-tuning these spatiotemporal patters remains unclear. Here, we performed comprehensive exploration of spatio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46975-5 |
| _version_ | 1797219721238544384 |
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| author | Liang Shi Xiaoxi Fu Shen Gui Tong Wan Junjie Zhuo Jinling Lu Pengcheng Li |
| author_facet | Liang Shi Xiaoxi Fu Shen Gui Tong Wan Junjie Zhuo Jinling Lu Pengcheng Li |
| author_sort | Liang Shi |
| collection | DOAJ |
| description | Abstract Increasing evidence has revealed the large-scale nonstationary synchronizations as traveling waves in spontaneous neural activity. However, the interplay of various cell types in fine-tuning these spatiotemporal patters remains unclear. Here, we performed comprehensive exploration of spatiotemporal synchronizing structures across different cell types, states (awake, anesthesia, motion) and developmental axis in male mice. We found traveling waves in glutamatergic neurons exhibited greater variety than those in GABAergic neurons. Moreover, the synchronizing structures of GABAergic neurons converged toward those of glutamatergic neurons during development, but the evolution of waves exhibited varying timelines for different sub-type interneurons. Functional connectivity arises from both standing and traveling waves, and negative connections can be elucidated by the spatial propagation of waves. In addition, some traveling waves were correlated with the spatial distribution of gene expression. Our findings offer further insights into the neural underpinnings of traveling waves, functional connectivity, and resting-state networks, with cell-type specificity and developmental perspectives. |
| first_indexed | 2024-04-24T12:38:09Z |
| format | Article |
| id | doaj.art-310eddd1b09148a6b09aa65702d46330 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T12:38:09Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-310eddd1b09148a6b09aa65702d463302024-04-07T11:23:19ZengNature PortfolioNature Communications2041-17232024-04-0115111710.1038/s41467-024-46975-5Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell typesLiang Shi0Xiaoxi Fu1Shen Gui2Tong Wan3Junjie Zhuo4Jinling Lu5Pengcheng Li6Britton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyBritton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyBritton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan UniversityState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan UniversityBritton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyBritton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and TechnologyAbstract Increasing evidence has revealed the large-scale nonstationary synchronizations as traveling waves in spontaneous neural activity. However, the interplay of various cell types in fine-tuning these spatiotemporal patters remains unclear. Here, we performed comprehensive exploration of spatiotemporal synchronizing structures across different cell types, states (awake, anesthesia, motion) and developmental axis in male mice. We found traveling waves in glutamatergic neurons exhibited greater variety than those in GABAergic neurons. Moreover, the synchronizing structures of GABAergic neurons converged toward those of glutamatergic neurons during development, but the evolution of waves exhibited varying timelines for different sub-type interneurons. Functional connectivity arises from both standing and traveling waves, and negative connections can be elucidated by the spatial propagation of waves. In addition, some traveling waves were correlated with the spatial distribution of gene expression. Our findings offer further insights into the neural underpinnings of traveling waves, functional connectivity, and resting-state networks, with cell-type specificity and developmental perspectives.https://doi.org/10.1038/s41467-024-46975-5 |
| spellingShingle | Liang Shi Xiaoxi Fu Shen Gui Tong Wan Junjie Zhuo Jinling Lu Pengcheng Li Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types Nature Communications |
| title | Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| title_full | Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| title_fullStr | Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| title_full_unstemmed | Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| title_short | Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| title_sort | global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types |
| url | https://doi.org/10.1038/s41467-024-46975-5 |
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