Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer.
To evaluate the impact of diabetes on outcomes in colorectal cancer patients and to examine whether this association varies by the location of tumor (colon vs. rectum).This study includes 4,131 stage I-III colorectal cancer patients, treated between 1995 and 2007 (12.5% diabetic, 53% colon, 47% rect...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3566217?pdf=render |
| _version_ | 1819105972970323968 |
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| author | Justin Y Jeon Duck Hyoun Jeong Min Geun Park Ji-Won Lee Sang Hui Chu Ji-Hye Park Mi Kyung Lee Kaori Sato Jennifer A Ligibel Jeffrey A Meyerhardt Nam Kyu Kim |
| author_facet | Justin Y Jeon Duck Hyoun Jeong Min Geun Park Ji-Won Lee Sang Hui Chu Ji-Hye Park Mi Kyung Lee Kaori Sato Jennifer A Ligibel Jeffrey A Meyerhardt Nam Kyu Kim |
| author_sort | Justin Y Jeon |
| collection | DOAJ |
| description | To evaluate the impact of diabetes on outcomes in colorectal cancer patients and to examine whether this association varies by the location of tumor (colon vs. rectum).This study includes 4,131 stage I-III colorectal cancer patients, treated between 1995 and 2007 (12.5% diabetic, 53% colon, 47% rectal) in South Korea. Cox proportional hazards modeling was used to determine the prognostic influence of DM on survival endpoints.Colorectal cancer patients with DM had significantly worse disease-free survival (DFS) [hazard ratio (HR) 1.17, 95% confidence interval (CI): 1.00-1.37] compared with patients without DM. When considering colon and rectal cancer independently, DM was significantly associated with worse overall survival (OS) (HR: 1.46, 95% CI: 1.11-1.92), DFS (HR: 1.45, 95% CI: 1.15-1.84) and recurrence-free survival (RFS) (HR: 1.32, 95% CI: 0.98-1.76) in colon cancer patients. No association for OS, DFS or RFS was observed in rectal cancer patients. There was significant interaction of location of tumor (colon vs. rectal cancer) with DM on OS (P = 0.009) and DFS (P = 0.007).This study suggests that DM negatively impacts survival outcomes of patients with colon cancer but not rectal cancer. |
| first_indexed | 2024-12-22T02:30:45Z |
| format | Article |
| id | doaj.art-310f14dc5fa249a8b132cc91b9b9d349 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T02:30:45Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-310f14dc5fa249a8b132cc91b9b9d3492022-12-21T18:41:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5519610.1371/journal.pone.0055196Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer.Justin Y JeonDuck Hyoun JeongMin Geun ParkJi-Won LeeSang Hui ChuJi-Hye ParkMi Kyung LeeKaori SatoJennifer A LigibelJeffrey A MeyerhardtNam Kyu KimTo evaluate the impact of diabetes on outcomes in colorectal cancer patients and to examine whether this association varies by the location of tumor (colon vs. rectum).This study includes 4,131 stage I-III colorectal cancer patients, treated between 1995 and 2007 (12.5% diabetic, 53% colon, 47% rectal) in South Korea. Cox proportional hazards modeling was used to determine the prognostic influence of DM on survival endpoints.Colorectal cancer patients with DM had significantly worse disease-free survival (DFS) [hazard ratio (HR) 1.17, 95% confidence interval (CI): 1.00-1.37] compared with patients without DM. When considering colon and rectal cancer independently, DM was significantly associated with worse overall survival (OS) (HR: 1.46, 95% CI: 1.11-1.92), DFS (HR: 1.45, 95% CI: 1.15-1.84) and recurrence-free survival (RFS) (HR: 1.32, 95% CI: 0.98-1.76) in colon cancer patients. No association for OS, DFS or RFS was observed in rectal cancer patients. There was significant interaction of location of tumor (colon vs. rectal cancer) with DM on OS (P = 0.009) and DFS (P = 0.007).This study suggests that DM negatively impacts survival outcomes of patients with colon cancer but not rectal cancer.http://europepmc.org/articles/PMC3566217?pdf=render |
| spellingShingle | Justin Y Jeon Duck Hyoun Jeong Min Geun Park Ji-Won Lee Sang Hui Chu Ji-Hye Park Mi Kyung Lee Kaori Sato Jennifer A Ligibel Jeffrey A Meyerhardt Nam Kyu Kim Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. PLoS ONE |
| title | Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. |
| title_full | Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. |
| title_fullStr | Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. |
| title_full_unstemmed | Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. |
| title_short | Impact of diabetes on oncologic outcome of colorectal cancer patients: colon vs. rectal cancer. |
| title_sort | impact of diabetes on oncologic outcome of colorectal cancer patients colon vs rectal cancer |
| url | http://europepmc.org/articles/PMC3566217?pdf=render |
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