Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note
Abstract Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, th...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000600465&lng=en&tlng=en |
| _version_ | 1818231781139152896 |
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| author | Nathan Valle Soubihe Junior Agnes Afrodite S. Albuquerque Livia Arcêncio José Antonio Thomazini Andre Schmidt Paulo Roberto B. Evora |
| author_facet | Nathan Valle Soubihe Junior Agnes Afrodite S. Albuquerque Livia Arcêncio José Antonio Thomazini Andre Schmidt Paulo Roberto B. Evora |
| author_sort | Nathan Valle Soubihe Junior |
| collection | DOAJ |
| description | Abstract Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injection, standardize the technique and attest to the safety of the method. The adaptation consists of creating myocardial microlesions that allow for better fixation of stem cells. The objective of this technical note covers only the development of the needle and the histological quality of the biopsies. It has not been used in humans yet. |
| first_indexed | 2024-12-12T10:55:50Z |
| format | Article |
| id | doaj.art-31139f9606f34e1e956d68056f8bad7e |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-12-12T10:55:50Z |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-31139f9606f34e1e956d68056f8bad7e2022-12-22T00:26:39ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-974131646546710.5935/1678-9741.20160092S0102-76382016000600465Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical NoteNathan Valle Soubihe JuniorAgnes Afrodite S. AlbuquerqueLivia ArcêncioJosé Antonio ThomaziniAndre SchmidtPaulo Roberto B. EvoraAbstract Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injection, standardize the technique and attest to the safety of the method. The adaptation consists of creating myocardial microlesions that allow for better fixation of stem cells. The objective of this technical note covers only the development of the needle and the histological quality of the biopsies. It has not been used in humans yet.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000600465&lng=en&tlng=enStem CellsBiopsyMyocardium |
| spellingShingle | Nathan Valle Soubihe Junior Agnes Afrodite S. Albuquerque Livia Arcêncio José Antonio Thomazini Andre Schmidt Paulo Roberto B. Evora Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note Brazilian Journal of Cardiovascular Surgery Stem Cells Biopsy Myocardium |
| title | Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note |
| title_full | Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note |
| title_fullStr | Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note |
| title_full_unstemmed | Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note |
| title_short | Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note |
| title_sort | development of a multifunctional needle for percutaneous heart biopsy and cell therapy a technical note |
| topic | Stem Cells Biopsy Myocardium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000600465&lng=en&tlng=en |
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