Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function
Background/AimsPatients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.Materials and...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.889489/full |
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| author | Mats L. Wiese Simone Gärtner Nele von Essen Julia Doller Fabian Frost Quang Trung Tran Quang Trung Tran Frank Ulrich Weiss Fatuma Meyer Luzia Valentini Leif-A. Garbe Cornelia C. Metges Karen Bannert Lea Franziska Sautter Luise Ehlers Robert Jaster Georg Lamprecht Antje Steveling Markus M. Lerch Markus M. Lerch Ali A. Aghdassi |
| author_facet | Mats L. Wiese Simone Gärtner Nele von Essen Julia Doller Fabian Frost Quang Trung Tran Quang Trung Tran Frank Ulrich Weiss Fatuma Meyer Luzia Valentini Leif-A. Garbe Cornelia C. Metges Karen Bannert Lea Franziska Sautter Luise Ehlers Robert Jaster Georg Lamprecht Antje Steveling Markus M. Lerch Markus M. Lerch Ali A. Aghdassi |
| author_sort | Mats L. Wiese |
| collection | DOAJ |
| description | Background/AimsPatients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.Materials and MethodsIn a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Malnutrition was diagnosed according to the criteria proposed by the Global Leadership Initiative on Malnutrition. We performed detailed examinations of body composition and physical function as well as testing of routine blood parameters and markers of inflammation.ResultsWe included 66 patients [mean (±SD) age: 56.0 (±14.5) years; 51 males] and an equal number of age- and sex-matched controls. Moderate malnutrition was diagnosed in 21% (n = 14) and severe malnutrition in 42% (n = 28) of patients. Besides weight loss malnourished patients showed lower fat and skeletal muscle mass compared to both non-malnourished subjects and healthy controls. Only in severe malnutrition, blood parameters reflected elevated inflammation and reduced muscle reserves. Handgrip strength in patients did not differ by nutritional status but there was a significant correlation (rho = 0.705, p < 0.001) with skeletal muscle mass. Although 20 patients (30%) had pathologically reduced skeletal muscle mass, only two individuals (3%) had sarcopenia with concomitantly reduced handgrip strength.ConclusionMalnutrition is a frequent complication of CP characterized by loss of skeletal muscle mass. As this condition becomes evident only at an advanced stage, regular testing for altered body composition is recommended. Suitable biomarkers and the link between loss of muscle mass and physical function require further investigation.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT04474743], identifier [NCT04474743]. |
| first_indexed | 2024-04-13T18:03:22Z |
| format | Article |
| id | doaj.art-3113fd8fe2eb4b8a9844dc7d263ba197 |
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| language | English |
| last_indexed | 2024-04-13T18:03:22Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-3113fd8fe2eb4b8a9844dc7d263ba1972022-12-22T02:36:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-06-01910.3389/fnut.2022.889489889489Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical FunctionMats L. Wiese0Simone Gärtner1Nele von Essen2Julia Doller3Fabian Frost4Quang Trung Tran5Quang Trung Tran6Frank Ulrich Weiss7Fatuma Meyer8Luzia Valentini9Leif-A. Garbe10Cornelia C. Metges11Karen Bannert12Lea Franziska Sautter13Luise Ehlers14Robert Jaster15Georg Lamprecht16Antje Steveling17Markus M. Lerch18Markus M. Lerch19Ali A. Aghdassi20Department of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue, VietnamDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyInstitute of Evidence-Based Dietetics (NIED), University of Applied Sciences Neubrandenburg, Neubrandenburg, GermanyInstitute of Evidence-Based Dietetics (NIED), University of Applied Sciences Neubrandenburg, Neubrandenburg, GermanyDepartment of Agriculture and Food Sciences, University of Applied Sciences Neubrandenburg, Neubrandenburg, GermanyInstitute of Nutritional Physiology “Oskar Kellner”, Research Institute for Farm Animal Biology (FBN), Dummerstorf, GermanyDepartment of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, GermanyDepartment of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, GermanyDepartment of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, GermanyDepartment of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, GermanyDepartment of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Rostock, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyLudwig Maximilian University Hospital, Ludwig Maximilian University of Munich, Munich, GermanyDepartment of Medicine A, University Medicine Greifswald, Greifswald, GermanyBackground/AimsPatients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.Materials and MethodsIn a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Malnutrition was diagnosed according to the criteria proposed by the Global Leadership Initiative on Malnutrition. We performed detailed examinations of body composition and physical function as well as testing of routine blood parameters and markers of inflammation.ResultsWe included 66 patients [mean (±SD) age: 56.0 (±14.5) years; 51 males] and an equal number of age- and sex-matched controls. Moderate malnutrition was diagnosed in 21% (n = 14) and severe malnutrition in 42% (n = 28) of patients. Besides weight loss malnourished patients showed lower fat and skeletal muscle mass compared to both non-malnourished subjects and healthy controls. Only in severe malnutrition, blood parameters reflected elevated inflammation and reduced muscle reserves. Handgrip strength in patients did not differ by nutritional status but there was a significant correlation (rho = 0.705, p < 0.001) with skeletal muscle mass. Although 20 patients (30%) had pathologically reduced skeletal muscle mass, only two individuals (3%) had sarcopenia with concomitantly reduced handgrip strength.ConclusionMalnutrition is a frequent complication of CP characterized by loss of skeletal muscle mass. As this condition becomes evident only at an advanced stage, regular testing for altered body composition is recommended. Suitable biomarkers and the link between loss of muscle mass and physical function require further investigation.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT04474743], identifier [NCT04474743].https://www.frontiersin.org/articles/10.3389/fnut.2022.889489/fullmalnutritionchronic pancreatitissarcopeniaGLIMhandgrip strength |
| spellingShingle | Mats L. Wiese Simone Gärtner Nele von Essen Julia Doller Fabian Frost Quang Trung Tran Quang Trung Tran Frank Ulrich Weiss Fatuma Meyer Luzia Valentini Leif-A. Garbe Cornelia C. Metges Karen Bannert Lea Franziska Sautter Luise Ehlers Robert Jaster Georg Lamprecht Antje Steveling Markus M. Lerch Markus M. Lerch Ali A. Aghdassi Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function Frontiers in Nutrition malnutrition chronic pancreatitis sarcopenia GLIM handgrip strength |
| title | Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function |
| title_full | Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function |
| title_fullStr | Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function |
| title_full_unstemmed | Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function |
| title_short | Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function |
| title_sort | malnutrition is highly prevalent in patients with chronic pancreatitis and characterized by loss of skeletal muscle mass but absence of impaired physical function |
| topic | malnutrition chronic pancreatitis sarcopenia GLIM handgrip strength |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.889489/full |
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