Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i>
Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/10/2372 |
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| author | Maël Gainche Isabelle Ripoche François Senejoux Juliette Cholet Clémence Ogeron Caroline Decombat Ombeline Danton Laetitia Delort Marjolaine Vareille-Delarbre Alexandre Berry Marion Vermerie Didier Fraisse Catherine Felgines Edwige Ranouille Jean-Yves Berthon Julien Priam Etienne Saunier Albert Tourrette Yves Troin Florence Caldefie-Chezet Pierre Chalard |
| author_facet | Maël Gainche Isabelle Ripoche François Senejoux Juliette Cholet Clémence Ogeron Caroline Decombat Ombeline Danton Laetitia Delort Marjolaine Vareille-Delarbre Alexandre Berry Marion Vermerie Didier Fraisse Catherine Felgines Edwige Ranouille Jean-Yves Berthon Julien Priam Etienne Saunier Albert Tourrette Yves Troin Florence Caldefie-Chezet Pierre Chalard |
| author_sort | Maël Gainche |
| collection | DOAJ |
| description | Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. <i>Luzula sylvatica</i>, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of <i>L. sylvatica</i> aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin <b>1</b> and eight phenanthrene derivatives (<b>2</b>–<b>9</b>), including four new compounds (<b>4</b>, <b>5</b>, <b>8</b> and <b>9</b>), from <i>n</i>-hexane and CH<sub>2</sub>Cl<sub>2</sub>, fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives <b>4</b>, <b>6,</b> and <b>7</b> showed very promising antiproliferative activities. |
| first_indexed | 2024-03-10T19:42:34Z |
| format | Article |
| id | doaj.art-31145bbf1e0a42f8ab207f1976a4ca70 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:42:34Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-31145bbf1e0a42f8ab207f1976a4ca702023-11-20T01:07:40ZengMDPI AGMolecules1420-30492020-05-012510237210.3390/molecules25102372Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i>Maël Gainche0Isabelle Ripoche1François Senejoux2Juliette Cholet3Clémence Ogeron4Caroline Decombat5Ombeline Danton6Laetitia Delort7Marjolaine Vareille-Delarbre8Alexandre Berry9Marion Vermerie10Didier Fraisse11Catherine Felgines12Edwige Ranouille13Jean-Yves Berthon14Julien Priam15Etienne Saunier16Albert Tourrette17Yves Troin18Florence Caldefie-Chezet19Pierre Chalard20Université Clermont-Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FrancePharmaceutical Biology, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, SwitzerlandUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceGreentech, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, FranceGreentech, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, FranceDômes Pharma, 3 Rue André Citroën, 63430 Pont-du-Château, FranceDômes Pharma, 3 Rue André Citroën, 63430 Pont-du-Château, FranceAltoPhyto, 7 rue des Gargailles, 63370 Lempdes, FranceUniversité Clermont-Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, FrancePhenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. <i>Luzula sylvatica</i>, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of <i>L. sylvatica</i> aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin <b>1</b> and eight phenanthrene derivatives (<b>2</b>–<b>9</b>), including four new compounds (<b>4</b>, <b>5</b>, <b>8</b> and <b>9</b>), from <i>n</i>-hexane and CH<sub>2</sub>Cl<sub>2</sub>, fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives <b>4</b>, <b>6,</b> and <b>7</b> showed very promising antiproliferative activities.https://www.mdpi.com/1420-3049/25/10/2372phenanthrene derivativesantiproliferative activities<i>Luzula sylvatica</i> |
| spellingShingle | Maël Gainche Isabelle Ripoche François Senejoux Juliette Cholet Clémence Ogeron Caroline Decombat Ombeline Danton Laetitia Delort Marjolaine Vareille-Delarbre Alexandre Berry Marion Vermerie Didier Fraisse Catherine Felgines Edwige Ranouille Jean-Yves Berthon Julien Priam Etienne Saunier Albert Tourrette Yves Troin Florence Caldefie-Chezet Pierre Chalard Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> Molecules phenanthrene derivatives antiproliferative activities <i>Luzula sylvatica</i> |
| title | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> |
| title_full | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> |
| title_fullStr | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> |
| title_full_unstemmed | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> |
| title_short | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from <i>Luzula sylvatica</i> |
| title_sort | anti inflammatory and cytotoxic potential of new phenanthrenoids from i luzula sylvatica i |
| topic | phenanthrene derivatives antiproliferative activities <i>Luzula sylvatica</i> |
| url | https://www.mdpi.com/1420-3049/25/10/2372 |
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