Time Course of Treatment for Primary Enuresis With Overactive Bladder
Purpose To characterize the course of treatment for nonmonosymptomatic enuresis with overactive bladder (OAB) in a real clinical setting. Methods Data from 111 OAB patients with moderate to severe enuresis were analyzed. The baseline analysis included a questionnaire, voiding diary, uroflowmetry wit...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2018-06-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-1836020-010.pdf |
| _version_ | 1818191164923183104 |
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| author | Young Jae Im Jung Keun Lee Kwanjin Park |
| author_facet | Young Jae Im Jung Keun Lee Kwanjin Park |
| author_sort | Young Jae Im |
| collection | DOAJ |
| description | Purpose To characterize the course of treatment for nonmonosymptomatic enuresis with overactive bladder (OAB) in a real clinical setting. Methods Data from 111 OAB patients with moderate to severe enuresis were analyzed. The baseline analysis included a questionnaire, voiding diary, uroflowmetry with postvoid residual urine measurement, and plain abdominal radiography of the kidneys, ureters, and bladder (KUB). Following standard urotherapy for 1 month, anticholinergic medication was administered with or without laxatives. Desmopressin was added if there was a partial response to OAB. Patients were followed every 3 months to evaluate the status of OAB and enuresis. Multivariate analysis was performed to identify predictors associated with the lack of complete response (CR) in enuresis at 12 months. Results Following 12 months of treatment, 64% and 88% of patients experienced at least partial response in enuresis and OAB, respectively. Urgency improved more quickly than enuresis, supporting the need to address daytime symptoms before enuresis. Seventy-nine patients (71%) had fecal impaction on KUB and/or subjective constipation. The combination of anticholinergics with either laxatives or desmopressin fared better than anticholinergics alone. Daytime incontinence and anticholinergics-only treatment were associated with a lack of CR during 12 months of treatment. Conclusions The data confirmed the validity of addressing OAB before treating enuresis. The results of this study also highlight the need to address fecal impaction. Patients should be counseled about the need for a prolonged course of treatment before starting treatment. Anticholinergics should be accompanied with either desmopressin or laxatives for better control of enuresis. |
| first_indexed | 2024-12-12T00:10:16Z |
| format | Article |
| id | doaj.art-3119758e933a413899c4adfe700def3a |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-12T00:10:16Z |
| publishDate | 2018-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-3119758e933a413899c4adfe700def3a2022-12-22T00:44:59ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312018-06-0122210711310.5213/inj.1836020.010721Time Course of Treatment for Primary Enuresis With Overactive BladderYoung Jae Im0Jung Keun Lee1Kwanjin Park2 Department of Urology, Seoul National University College of Medicine, Seoul, Korea Department of Urology, Seoul National University College of Medicine, Seoul, Korea Department of Urology, Seoul National University College of Medicine, Seoul, KoreaPurpose To characterize the course of treatment for nonmonosymptomatic enuresis with overactive bladder (OAB) in a real clinical setting. Methods Data from 111 OAB patients with moderate to severe enuresis were analyzed. The baseline analysis included a questionnaire, voiding diary, uroflowmetry with postvoid residual urine measurement, and plain abdominal radiography of the kidneys, ureters, and bladder (KUB). Following standard urotherapy for 1 month, anticholinergic medication was administered with or without laxatives. Desmopressin was added if there was a partial response to OAB. Patients were followed every 3 months to evaluate the status of OAB and enuresis. Multivariate analysis was performed to identify predictors associated with the lack of complete response (CR) in enuresis at 12 months. Results Following 12 months of treatment, 64% and 88% of patients experienced at least partial response in enuresis and OAB, respectively. Urgency improved more quickly than enuresis, supporting the need to address daytime symptoms before enuresis. Seventy-nine patients (71%) had fecal impaction on KUB and/or subjective constipation. The combination of anticholinergics with either laxatives or desmopressin fared better than anticholinergics alone. Daytime incontinence and anticholinergics-only treatment were associated with a lack of CR during 12 months of treatment. Conclusions The data confirmed the validity of addressing OAB before treating enuresis. The results of this study also highlight the need to address fecal impaction. Patients should be counseled about the need for a prolonged course of treatment before starting treatment. Anticholinergics should be accompanied with either desmopressin or laxatives for better control of enuresis.http://www.einj.org/upload/pdf/inj-1836020-010.pdfConstipationEnuresisAnticholinergicsUrinary bladder, Overactive |
| spellingShingle | Young Jae Im Jung Keun Lee Kwanjin Park Time Course of Treatment for Primary Enuresis With Overactive Bladder International Neurourology Journal Constipation Enuresis Anticholinergics Urinary bladder, Overactive |
| title | Time Course of Treatment for Primary Enuresis With Overactive Bladder |
| title_full | Time Course of Treatment for Primary Enuresis With Overactive Bladder |
| title_fullStr | Time Course of Treatment for Primary Enuresis With Overactive Bladder |
| title_full_unstemmed | Time Course of Treatment for Primary Enuresis With Overactive Bladder |
| title_short | Time Course of Treatment for Primary Enuresis With Overactive Bladder |
| title_sort | time course of treatment for primary enuresis with overactive bladder |
| topic | Constipation Enuresis Anticholinergics Urinary bladder, Overactive |
| url | http://www.einj.org/upload/pdf/inj-1836020-010.pdf |
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