Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study
CONTEXT AND OBJECTIVE: The pineal gland is an adaptive organ that precisely regulates the biological rhythms of melatonin brain hemostasis. Variation in the regulation of melatonin rhythms is a likely cause of depressive disorder. The purpose of this study was to measure serum melatonin levels in pa...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000300006&lng=en&tlng=en |
| _version_ | 1818026133990408192 |
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| author | Shahnaz Khaleghipour Mohsen Masjedi Hassan Ahade Meersalahodin Enayate Gholamreza Pasha Farah Nadery Gholamhossein Ahmadzade |
| author_facet | Shahnaz Khaleghipour Mohsen Masjedi Hassan Ahade Meersalahodin Enayate Gholamreza Pasha Farah Nadery Gholamhossein Ahmadzade |
| author_sort | Shahnaz Khaleghipour |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: The pineal gland is an adaptive organ that precisely regulates the biological rhythms of melatonin brain hemostasis. Variation in the regulation of melatonin rhythms is a likely cause of depressive disorder. The purpose of this study was to measure serum melatonin levels in patients with major depressive disorder (MDD) and normal control subjects. DESIGN AND SETTING: Analytical cross-sectional study at the industrial medical unit of the Iron Smelting Company of Isfahan, Iran. METHODS: The morning and nocturnal serum melatonin levels of patients and controls were measured using the enzyme-linked immunosorbent assay (ELISA) method. All data were assessed using variance analysis. RESULTS: The morning and nocturnal serum melatonin levels of depressed and healthy subjects differed (P < 0.05). The nocturnal serum melatonin levels of depressed women were lower than those of depressed men (P < 0.05). CONCLUSIONS: The findings of this study showed that the nocturnal serum melatonin levels in the depressed patients were lower than in the controls. Thus, the peak melatonin phase in the depressed patients was reached with delay. CLINICAL TRIAL REGISTRATION NUMBER: NCT01357083 |
| first_indexed | 2024-12-10T04:27:10Z |
| format | Article |
| id | doaj.art-3119ae67ec224e96b28752d77418af4a |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-10T04:27:10Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-3119ae67ec224e96b28752d77418af4a2022-12-22T02:02:15ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460130316717210.1590/S1516-31802012000300006S1516-31802012000300006Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional studyShahnaz Khaleghipour0Mohsen Masjedi1Hassan Ahade2Meersalahodin Enayate3Gholamreza Pasha4Farah Nadery5Gholamhossein Ahmadzade6Islamic Azad UniversityIsfahan University of Medical SciencesAlame Tabatabaei UniversityIslamic Azad UniversityIslamic Azad UniversityIslamic Azad UniversityIsfahan University of Medical SciencesCONTEXT AND OBJECTIVE: The pineal gland is an adaptive organ that precisely regulates the biological rhythms of melatonin brain hemostasis. Variation in the regulation of melatonin rhythms is a likely cause of depressive disorder. The purpose of this study was to measure serum melatonin levels in patients with major depressive disorder (MDD) and normal control subjects. DESIGN AND SETTING: Analytical cross-sectional study at the industrial medical unit of the Iron Smelting Company of Isfahan, Iran. METHODS: The morning and nocturnal serum melatonin levels of patients and controls were measured using the enzyme-linked immunosorbent assay (ELISA) method. All data were assessed using variance analysis. RESULTS: The morning and nocturnal serum melatonin levels of depressed and healthy subjects differed (P < 0.05). The nocturnal serum melatonin levels of depressed women were lower than those of depressed men (P < 0.05). CONCLUSIONS: The findings of this study showed that the nocturnal serum melatonin levels in the depressed patients were lower than in the controls. Thus, the peak melatonin phase in the depressed patients was reached with delay. CLINICAL TRIAL REGISTRATION NUMBER: NCT01357083http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000300006&lng=en&tlng=enMelatoninaPeriodicidadTrastorno depresivo mayorSueroDepresión |
| spellingShingle | Shahnaz Khaleghipour Mohsen Masjedi Hassan Ahade Meersalahodin Enayate Gholamreza Pasha Farah Nadery Gholamhossein Ahmadzade Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study São Paulo Medical Journal Melatonina Periodicidad Trastorno depresivo mayor Suero Depresión |
| title | Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study |
| title_full | Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study |
| title_fullStr | Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study |
| title_full_unstemmed | Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study |
| title_short | Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study |
| title_sort | morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder an analytical cross sectional study |
| topic | Melatonina Periodicidad Trastorno depresivo mayor Suero Depresión |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000300006&lng=en&tlng=en |
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