Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans[S]

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans[S]

While genetic determinants strongly influence HDL cholesterol (HDLc) levels, most genetic causes underlying variation in HDLc remain unknown. We aimed to identify novel rare mutations with large effects in candidate genes contributing to extreme HDLc in humans, utilizing family-based Mendelian genet...

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Hlavní autoři: Roshni R. Singaraja, Ian Tietjen, G. Kees Hovingh, Patrick L. Franchini, Chris Radomski, Kenny Wong, Margaret vanHeek, Ioannis M. Stylianou, Linus Lin, Liangsu Wang, Lyndon Mitnaul, Brian Hubbard, Michael Winther, Maryanne Mattice, Annick Legendre, Robin Sherrington, John J. Kastelein, Karen Akinsanya, Andrew Plump, Michael R. Hayden
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2014-08-01
Edice:Journal of Lipid Research
Témata:
high density lipoprotein
Mendelian genetics
lipids
high density lipoprotein metabolism
genetics
lipoproteins
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0022227520353323

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520353323

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