Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine
Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. Researchers are now har...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-05-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/5/2/15 |
| _version_ | 1827847956327301120 |
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| author | Bryant C. Nelson Monique E. Johnson Marlon L. Walker Kathryn R. Riley Christopher M. Sims |
| author_facet | Bryant C. Nelson Monique E. Johnson Marlon L. Walker Kathryn R. Riley Christopher M. Sims |
| author_sort | Bryant C. Nelson |
| collection | DOAJ |
| description | Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. Researchers are now harnessing the catalytic repertoire of CNPs to develop potential new treatment modalities for both oxidative- and nitrosative-stress induced disorders and diseases. In order to reach the point where our experimental understanding of the antioxidant activity of CNPs can be translated into useful therapeutics in the clinic, it is necessary to evaluate the most current evidence that supports CNP antioxidant activity in biological systems. Accordingly, the aims of this review are three-fold: (1) To describe the putative reaction mechanisms and physicochemical surface properties that enable CNPs to both scavenge reactive oxygen species (ROS) and to act as antioxidant enzyme-like mimetics in solution; (2) To provide an overview, with commentary, regarding the most robust design and synthesis pathways for preparing CNPs with catalytic antioxidant activity; (3) To provide the reader with the most up-to-date in vitro and in vivo experimental evidence supporting the ROS-scavenging potential of CNPs in biology and medicine. |
| first_indexed | 2024-03-12T09:38:55Z |
| format | Article |
| id | doaj.art-311eedd306684a64ad701215e9034c5a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T09:38:55Z |
| publishDate | 2016-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-311eedd306684a64ad701215e9034c5a2023-09-02T13:22:27ZengMDPI AGAntioxidants2076-39212016-05-01521510.3390/antiox5020015antiox5020015Antioxidant Cerium Oxide Nanoparticles in Biology and MedicineBryant C. Nelson0Monique E. Johnson1Marlon L. Walker2Kathryn R. Riley3Christopher M. Sims4Material Measurement Laboratory—Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USAMaterial Measurement Laboratory—Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USAMaterial Measurement Laboratory—Materials Measurement Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USAMaterial Measurement Laboratory—Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USAMaterial Measurement Laboratory—Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USAPreviously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. Researchers are now harnessing the catalytic repertoire of CNPs to develop potential new treatment modalities for both oxidative- and nitrosative-stress induced disorders and diseases. In order to reach the point where our experimental understanding of the antioxidant activity of CNPs can be translated into useful therapeutics in the clinic, it is necessary to evaluate the most current evidence that supports CNP antioxidant activity in biological systems. Accordingly, the aims of this review are three-fold: (1) To describe the putative reaction mechanisms and physicochemical surface properties that enable CNPs to both scavenge reactive oxygen species (ROS) and to act as antioxidant enzyme-like mimetics in solution; (2) To provide an overview, with commentary, regarding the most robust design and synthesis pathways for preparing CNPs with catalytic antioxidant activity; (3) To provide the reader with the most up-to-date in vitro and in vivo experimental evidence supporting the ROS-scavenging potential of CNPs in biology and medicine.http://www.mdpi.com/2076-3921/5/2/15nanoceriacerium oxide nanoparticlesreactive oxygen speciesenzyme mimeticsredox-cycling |
| spellingShingle | Bryant C. Nelson Monique E. Johnson Marlon L. Walker Kathryn R. Riley Christopher M. Sims Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine Antioxidants nanoceria cerium oxide nanoparticles reactive oxygen species enzyme mimetics redox-cycling |
| title | Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine |
| title_full | Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine |
| title_fullStr | Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine |
| title_full_unstemmed | Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine |
| title_short | Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine |
| title_sort | antioxidant cerium oxide nanoparticles in biology and medicine |
| topic | nanoceria cerium oxide nanoparticles reactive oxygen species enzyme mimetics redox-cycling |
| url | http://www.mdpi.com/2076-3921/5/2/15 |
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