Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/12/4740 |
| _version_ | 1797593298543575040 |
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| author | Ying Chen Hongyan Li Ke Wang Yousheng Wang |
| author_facet | Ying Chen Hongyan Li Ke Wang Yousheng Wang |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions. |
| first_indexed | 2024-03-11T02:06:04Z |
| format | Article |
| id | doaj.art-311f0c9fdc5d4182b17b8853a2da5718 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:06:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-311f0c9fdc5d4182b17b8853a2da57182023-11-18T11:49:41ZengMDPI AGMolecules1420-30492023-06-012812474010.3390/molecules28124740Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3Ying Chen0Hongyan Li1Ke Wang2Yousheng Wang3Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, ChinaOrganic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.https://www.mdpi.com/1420-3049/28/12/4740organic anion transporter 3drug–drug interactionsherb–drug interactionsnatural active compoundsinhibitors |
| spellingShingle | Ying Chen Hongyan Li Ke Wang Yousheng Wang Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 Molecules organic anion transporter 3 drug–drug interactions herb–drug interactions natural active compounds inhibitors |
| title | Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 |
| title_full | Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 |
| title_fullStr | Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 |
| title_full_unstemmed | Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 |
| title_short | Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 |
| title_sort | recent advances in synthetic drugs and natural actives interacting with oat3 |
| topic | organic anion transporter 3 drug–drug interactions herb–drug interactions natural active compounds inhibitors |
| url | https://www.mdpi.com/1420-3049/28/12/4740 |
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