Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis
BackgroundAlzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are aging related diseases with high incidence. Because of the correlation of incidence rate and some possible mechanisms of comorbidity, the two diseases have been studied in combination by many researchers, and even some schola...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1301778/full |
| _version_ | 1827594479641559040 |
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| author | Hao Xie Ying Yu Yang Yang Qian Sun Ze-Yang Li Min-Hua Ni Si-Ning Li Si-Ning Li Pan Dai Pan Dai Yan-Yan Cui Yan-Yan Cui Xin-Yu Cao Xin-Yu Cao Nan Jiang Li-Juan Du Wen Gao Jia-Jun Bi Lin-Feng Yan Guang-Bin Cui |
| author_facet | Hao Xie Ying Yu Yang Yang Qian Sun Ze-Yang Li Min-Hua Ni Si-Ning Li Si-Ning Li Pan Dai Pan Dai Yan-Yan Cui Yan-Yan Cui Xin-Yu Cao Xin-Yu Cao Nan Jiang Li-Juan Du Wen Gao Jia-Jun Bi Lin-Feng Yan Guang-Bin Cui |
| author_sort | Hao Xie |
| collection | DOAJ |
| description | BackgroundAlzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are aging related diseases with high incidence. Because of the correlation of incidence rate and some possible mechanisms of comorbidity, the two diseases have been studied in combination by many researchers, and even some scholars call AD type 3 diabetes. But the relationship between the two is still controversial.MethodsThis study used seed-based d mapping software to conduct a meta-analysis of the whole brain resting state functional magnetic resonance imaging (rs-fMRI) study, exploring the differences in amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF) between patients (AD or T2DM) and healthy controls (HCs), and searching for neuroimaging evidence that can explain the relationship between the two diseases.ResultsThe final study included 22 datasets of ALFF and 22 datasets of CBF. The results of T2DM group showed that ALFF increased in both cerebellum and left inferior temporal gyrus regions, but decreased in left middle occipital gyrus, right inferior occipital gyrus, and left anterior central gyrus regions. In the T2DM group, CBF increased in the right supplementary motor area, while decreased in the middle occipital gyrus and inferior parietal gyrus. The results of the AD group showed that the ALFF increased in the right cerebellum, right hippocampus, and right striatum, while decreased in the precuneus gyrus and right superior temporal gyrus. In the AD group, CBF in the anterior precuneus gyrus and inferior parietal gyrus decreased. Multimodal analysis within a disease showed that ALFF and CBF both decreased in the occipital lobe of the T2DM group and in the precuneus and parietal lobe of the AD group. In addition, there was a common decrease of CBF in the right middle occipital gyrus in both groups.ConclusionBased on neuroimaging evidence, we believe that T2DM and AD are two diseases with their respective characteristics of central nervous activity and cerebral perfusion. The changes in CBF between the two diseases partially overlap, which is consistent with their respective clinical characteristics and also indicates a close relationship between them.Systematic review registrationPROSPERO [CRD42022370014]. |
| first_indexed | 2024-03-09T02:36:11Z |
| format | Article |
| id | doaj.art-312117a487da4cf798d1c954e25e142b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-09T02:36:11Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-312117a487da4cf798d1c954e25e142b2023-12-06T08:30:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-12-011710.3389/fnins.2023.13017781301778Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysisHao Xie0Ying Yu1Yang Yang2Qian Sun3Ze-Yang Li4Min-Hua Ni5Si-Ning Li6Si-Ning Li7Pan Dai8Pan Dai9Yan-Yan Cui10Yan-Yan Cui11Xin-Yu Cao12Xin-Yu Cao13Nan Jiang14Li-Juan Du15Wen Gao16Jia-Jun Bi17Lin-Feng Yan18Guang-Bin Cui19Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaFaculty of Medical Technology, Xi’an Medical University, Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaFaculty of Medical Technology, Xi’an Medical University, Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaFaculty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaFaculty of Medical Technology, Medical School of Yan’an University, Yan’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaStudent Brigade, Fourth Military Medical University, Xi’an, Shaanxi, ChinaStudent Brigade, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, Shaanxi, ChinaBackgroundAlzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are aging related diseases with high incidence. Because of the correlation of incidence rate and some possible mechanisms of comorbidity, the two diseases have been studied in combination by many researchers, and even some scholars call AD type 3 diabetes. But the relationship between the two is still controversial.MethodsThis study used seed-based d mapping software to conduct a meta-analysis of the whole brain resting state functional magnetic resonance imaging (rs-fMRI) study, exploring the differences in amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF) between patients (AD or T2DM) and healthy controls (HCs), and searching for neuroimaging evidence that can explain the relationship between the two diseases.ResultsThe final study included 22 datasets of ALFF and 22 datasets of CBF. The results of T2DM group showed that ALFF increased in both cerebellum and left inferior temporal gyrus regions, but decreased in left middle occipital gyrus, right inferior occipital gyrus, and left anterior central gyrus regions. In the T2DM group, CBF increased in the right supplementary motor area, while decreased in the middle occipital gyrus and inferior parietal gyrus. The results of the AD group showed that the ALFF increased in the right cerebellum, right hippocampus, and right striatum, while decreased in the precuneus gyrus and right superior temporal gyrus. In the AD group, CBF in the anterior precuneus gyrus and inferior parietal gyrus decreased. Multimodal analysis within a disease showed that ALFF and CBF both decreased in the occipital lobe of the T2DM group and in the precuneus and parietal lobe of the AD group. In addition, there was a common decrease of CBF in the right middle occipital gyrus in both groups.ConclusionBased on neuroimaging evidence, we believe that T2DM and AD are two diseases with their respective characteristics of central nervous activity and cerebral perfusion. The changes in CBF between the two diseases partially overlap, which is consistent with their respective clinical characteristics and also indicates a close relationship between them.Systematic review registrationPROSPERO [CRD42022370014].https://www.frontiersin.org/articles/10.3389/fnins.2023.1301778/fullfunctional neuroimagingAlzheimer’s diseasetype 2 diabetes mellitusfunctional magnetic resonance imagingcoordinated-based meta-analysis |
| spellingShingle | Hao Xie Ying Yu Yang Yang Qian Sun Ze-Yang Li Min-Hua Ni Si-Ning Li Si-Ning Li Pan Dai Pan Dai Yan-Yan Cui Yan-Yan Cui Xin-Yu Cao Xin-Yu Cao Nan Jiang Li-Juan Du Wen Gao Jia-Jun Bi Lin-Feng Yan Guang-Bin Cui Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis Frontiers in Neuroscience functional neuroimaging Alzheimer’s disease type 2 diabetes mellitus functional magnetic resonance imaging coordinated-based meta-analysis |
| title | Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis |
| title_full | Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis |
| title_fullStr | Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis |
| title_full_unstemmed | Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis |
| title_short | Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis |
| title_sort | commonalities and distinctions between the type 2 diabetes mellitus and alzheimer s disease a systematic review and multimodal neuroimaging meta analysis |
| topic | functional neuroimaging Alzheimer’s disease type 2 diabetes mellitus functional magnetic resonance imaging coordinated-based meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1301778/full |
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