PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer
PIWI-interacting RNA (piRNAs), once thought to be mainly functioning in germlines, are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are wel...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220301240 |
| _version_ | 1827267399297007616 |
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| author | Jing-Fen Su Anthony Concilla Dian-zheng Zhang Fang Zhao Fang-Fang Shen Hao Zhang Fu-You Zhou |
| author_facet | Jing-Fen Su Anthony Concilla Dian-zheng Zhang Fang Zhao Fang-Fang Shen Hao Zhang Fu-You Zhou |
| author_sort | Jing-Fen Su |
| collection | DOAJ |
| description | PIWI-interacting RNA (piRNAs), once thought to be mainly functioning in germlines, are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals, including humans. By being involved in DNA methylation, histone marker deposition, mRNA degradation, and protein modification, piRNAs also contribute to carcinogenesis partly due to oncogenic stress-induced piRNA dysregulation. Also, piRNAs play important roles in cancer stemness, drug resistance, and tumor immunology. Results from liquid biopsy analysis of piRNA can be used in both cancer diagnoses and cancer prognoses. A combination of targeting piRNA with other therapeutic strategies could be groundbreaking cancer treatment. |
| first_indexed | 2024-03-12T10:18:29Z |
| format | Article |
| id | doaj.art-31232355ac8e4f7fa474e60c1f95844e |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:33:07Z |
| publishDate | 2021-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-31232355ac8e4f7fa474e60c1f95844e2024-04-28T02:13:49ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-09-0185603622PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancerJing-Fen Su0Anthony Concilla1Dian-zheng Zhang2Fang Zhao3Fang-Fang Shen4Hao Zhang5Fu-You Zhou6Anyang Key Laboratory for Esophageal Cancer Research, Anyang Cancer Hospital, The Forth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan Province, 455000, PR ChinaDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USADepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USAAnyang Key Laboratory for Esophageal Cancer Research, Anyang Cancer Hospital, The Forth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan Province, 455000, PR ChinaKey Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan Province, 453000, PR ChinaInstitute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, Guangdong Province, 510630, PR China; Corresponding author.Anyang Key Laboratory for Esophageal Cancer Research, Anyang Cancer Hospital, The Forth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan Province, 455000, PR China; Corresponding author.PIWI-interacting RNA (piRNAs), once thought to be mainly functioning in germlines, are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals, including humans. By being involved in DNA methylation, histone marker deposition, mRNA degradation, and protein modification, piRNAs also contribute to carcinogenesis partly due to oncogenic stress-induced piRNA dysregulation. Also, piRNAs play important roles in cancer stemness, drug resistance, and tumor immunology. Results from liquid biopsy analysis of piRNA can be used in both cancer diagnoses and cancer prognoses. A combination of targeting piRNA with other therapeutic strategies could be groundbreaking cancer treatment.http://www.sciencedirect.com/science/article/pii/S2352304220301240CarcinogenesisClinical utilityMitochondria-based phased productionPing-pong cyclePiwi-interacting RNAs |
| spellingShingle | Jing-Fen Su Anthony Concilla Dian-zheng Zhang Fang Zhao Fang-Fang Shen Hao Zhang Fu-You Zhou PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer Genes and Diseases Carcinogenesis Clinical utility Mitochondria-based phased production Ping-pong cycle Piwi-interacting RNAs |
| title | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer |
| title_full | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer |
| title_fullStr | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer |
| title_full_unstemmed | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer |
| title_short | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer |
| title_sort | piwi interacting rnas mitochondria based biogenesis and functions in cancer |
| topic | Carcinogenesis Clinical utility Mitochondria-based phased production Ping-pong cycle Piwi-interacting RNAs |
| url | http://www.sciencedirect.com/science/article/pii/S2352304220301240 |
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