Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives
Inflammation is an essential reaction of the immune system to infections and sterile tissue injury. However, uncontrolled or unresolved inflammation can cause tissue damage and contribute to the pathogenesis of various inflammatory diseases. Resolution of inflammation is driven by endogenous molecul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/1/75 |
| _version_ | 1797495454791892992 |
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| author | Layara Roberta Ferreira Duarte Vanessa Pinho Barbara Maximino Rezende Mauro Martins Teixeira |
| author_facet | Layara Roberta Ferreira Duarte Vanessa Pinho Barbara Maximino Rezende Mauro Martins Teixeira |
| author_sort | Layara Roberta Ferreira Duarte |
| collection | DOAJ |
| description | Inflammation is an essential reaction of the immune system to infections and sterile tissue injury. However, uncontrolled or unresolved inflammation can cause tissue damage and contribute to the pathogenesis of various inflammatory diseases. Resolution of inflammation is driven by endogenous molecules, known as pro-resolving mediators, that contribute to dampening inflammatory responses, promoting the resolution of inflammation and the recovery of tissue homeostasis. These mediators have been shown to be useful to decrease inflammatory responses and tissue damage in various models of inflammatory diseases. Graft-versus-host disease (GVHD) is a major unwanted reaction following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is characterized by an exacerbated inflammatory response provoked by antigen disparities between transplant recipient and donor. There is no fully effective treatment or prophylaxis for GVHD. This review explores the effects of several pro-resolving mediators and discusses their potential use as novel therapies in the context of GVHD. |
| first_indexed | 2024-03-10T01:49:51Z |
| format | Article |
| id | doaj.art-312430c03cf34901ae77d29249b95e38 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:49:51Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-312430c03cf34901ae77d29249b95e382023-11-23T13:06:40ZengMDPI AGBiomolecules2218-273X2022-01-011217510.3390/biom12010075Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and PerspectivesLayara Roberta Ferreira Duarte0Vanessa Pinho1Barbara Maximino Rezende2Mauro Martins Teixeira3Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilDepartamento de Enfermagem Básica, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, and Center for Advanced and Innovative Therapies, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilInflammation is an essential reaction of the immune system to infections and sterile tissue injury. However, uncontrolled or unresolved inflammation can cause tissue damage and contribute to the pathogenesis of various inflammatory diseases. Resolution of inflammation is driven by endogenous molecules, known as pro-resolving mediators, that contribute to dampening inflammatory responses, promoting the resolution of inflammation and the recovery of tissue homeostasis. These mediators have been shown to be useful to decrease inflammatory responses and tissue damage in various models of inflammatory diseases. Graft-versus-host disease (GVHD) is a major unwanted reaction following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is characterized by an exacerbated inflammatory response provoked by antigen disparities between transplant recipient and donor. There is no fully effective treatment or prophylaxis for GVHD. This review explores the effects of several pro-resolving mediators and discusses their potential use as novel therapies in the context of GVHD.https://www.mdpi.com/2218-273X/12/1/75resolutioninflammationGVHDpro-resolving mediators |
| spellingShingle | Layara Roberta Ferreira Duarte Vanessa Pinho Barbara Maximino Rezende Mauro Martins Teixeira Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives Biomolecules resolution inflammation GVHD pro-resolving mediators |
| title | Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives |
| title_full | Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives |
| title_fullStr | Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives |
| title_full_unstemmed | Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives |
| title_short | Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives |
| title_sort | resolution of inflammation in acute graft versus host disease advances and perspectives |
| topic | resolution inflammation GVHD pro-resolving mediators |
| url | https://www.mdpi.com/2218-273X/12/1/75 |
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