Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers
<i>Background and Objective:</i> Ovarian cancer is a leading cause of death in females. Since its treatment is challenging and causes severe side effects, novel therapies are urgently needed. One of the potential enzymes implicated in the progression of cancers is Cytochrome 4Z1 (CYP4Z1)...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/9/1263 |
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| author | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Anas O. Satari Yanal S. Al-mahdy Ghadeer H. Almuhaisen Omar H. Abu-azzam Ala N. Uwais Seham M. Abufraijeh Ahlam M. Al-Kharabsheh Sa’ed M. Al-dalain Aiman Al-Qtaitat Fatima Al-Tarawneh Jehad M. Al Shuneigat Sameeh A. Al-Sarayreh |
| author_facet | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Anas O. Satari Yanal S. Al-mahdy Ghadeer H. Almuhaisen Omar H. Abu-azzam Ala N. Uwais Seham M. Abufraijeh Ahlam M. Al-Kharabsheh Sa’ed M. Al-dalain Aiman Al-Qtaitat Fatima Al-Tarawneh Jehad M. Al Shuneigat Sameeh A. Al-Sarayreh |
| author_sort | Yousef M. Al-saraireh |
| collection | DOAJ |
| description | <i>Background and Objective:</i> Ovarian cancer is a leading cause of death in females. Since its treatment is challenging and causes severe side effects, novel therapies are urgently needed. One of the potential enzymes implicated in the progression of cancers is Cytochrome 4Z1 (CYP4Z1). Its expression in ovarian cancer remains unknown. Therefore, the current study aims to assess CYP4Z1 expression in different subtypes of ovarian cancers. <i>Materials and Methods</i>: Immunohistochemistry was used to characterize CYP4Z1 expression in 192 cases of ovarian cancers along with eight normal ovarian tissues. The enzyme’s association with various clinicopathological characteristics and survival was determined. <i>Results:</i> CYP4Z1 was strongly expressed in 79% of ovarian cancers, compared to negative expression in normal ovarian samples. Importantly, significantly high CYP4Z1 expres-sion was determined in patients with advanced-stage cancer and a high depth of invasion (<i>p</i> < 0.05). Surprisingly, CYP4Z1 expression was significantly associated with a low patient survival rate. Univariate analysis revealed that patient survival was strongly associated with CYP4Z1 expression, tumor stage, depth of invasion, and lymph node metastasis (<i>p</i> < 0.05). Multivariate analysis showed that only CYP4Z1 expression was significantly associated with patient survival (<i>p</i> < 0.05). <i>Conclusions:</i> CYP4Z1 expression is correlated with shorter patient survival and has been identified as an independent indicator of a poor prognosis for ovarian cancer patients. |
| first_indexed | 2024-03-09T23:13:28Z |
| format | Article |
| id | doaj.art-31246943cc5f4388b7c1b66d0ebcbf08 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:13:28Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-31246943cc5f4388b7c1b66d0ebcbf082023-11-23T17:40:40ZengMDPI AGMedicina1010-660X1648-91442022-09-01589126310.3390/medicina58091263Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian CancersYousef M. Al-saraireh0Fatemah O. F. O. Alshammari1Anas O. Satari2Yanal S. Al-mahdy3Ghadeer H. Almuhaisen4Omar H. Abu-azzam5Ala N. Uwais6Seham M. Abufraijeh7Ahlam M. Al-Kharabsheh8Sa’ed M. Al-dalain9Aiman Al-Qtaitat10Fatima Al-Tarawneh11Jehad M. Al Shuneigat12Sameeh A. Al-Sarayreh13Department of Pharmacology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Medical Lab Technology, Faculty of Health Sciences, The Public Authority for Applied Education and Training, Shuwaikh 15432, KuwaitFaculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanFaculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Microbiology and Pathology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Pharmacology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Anatomy and Histology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Allied Medical Sciences, Faculty of Al-Karak, Al-Balqa Applied University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, Jordan<i>Background and Objective:</i> Ovarian cancer is a leading cause of death in females. Since its treatment is challenging and causes severe side effects, novel therapies are urgently needed. One of the potential enzymes implicated in the progression of cancers is Cytochrome 4Z1 (CYP4Z1). Its expression in ovarian cancer remains unknown. Therefore, the current study aims to assess CYP4Z1 expression in different subtypes of ovarian cancers. <i>Materials and Methods</i>: Immunohistochemistry was used to characterize CYP4Z1 expression in 192 cases of ovarian cancers along with eight normal ovarian tissues. The enzyme’s association with various clinicopathological characteristics and survival was determined. <i>Results:</i> CYP4Z1 was strongly expressed in 79% of ovarian cancers, compared to negative expression in normal ovarian samples. Importantly, significantly high CYP4Z1 expres-sion was determined in patients with advanced-stage cancer and a high depth of invasion (<i>p</i> < 0.05). Surprisingly, CYP4Z1 expression was significantly associated with a low patient survival rate. Univariate analysis revealed that patient survival was strongly associated with CYP4Z1 expression, tumor stage, depth of invasion, and lymph node metastasis (<i>p</i> < 0.05). Multivariate analysis showed that only CYP4Z1 expression was significantly associated with patient survival (<i>p</i> < 0.05). <i>Conclusions:</i> CYP4Z1 expression is correlated with shorter patient survival and has been identified as an independent indicator of a poor prognosis for ovarian cancer patients.https://www.mdpi.com/1648-9144/58/9/1263cancerCytochrome P450Cytochrome 4Z1ImmunohistochemistryOvarian cancer |
| spellingShingle | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Anas O. Satari Yanal S. Al-mahdy Ghadeer H. Almuhaisen Omar H. Abu-azzam Ala N. Uwais Seham M. Abufraijeh Ahlam M. Al-Kharabsheh Sa’ed M. Al-dalain Aiman Al-Qtaitat Fatima Al-Tarawneh Jehad M. Al Shuneigat Sameeh A. Al-Sarayreh Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers Medicina cancer Cytochrome P450 Cytochrome 4Z1 Immunohistochemistry Ovarian cancer |
| title | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers |
| title_full | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers |
| title_fullStr | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers |
| title_full_unstemmed | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers |
| title_short | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers |
| title_sort | cytochrome 4z1 expression connotes unfavorable prognosis in ovarian cancers |
| topic | cancer Cytochrome P450 Cytochrome 4Z1 Immunohistochemistry Ovarian cancer |
| url | https://www.mdpi.com/1648-9144/58/9/1263 |
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