Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure
AbstractBackground A growing number of studies show that people with similar blood glucose levels have different levels of glycosylated haemoglobin (HbA1c), and relying only on HbA1c may lead to clinical decision-making errors. The haemoglobin glycation index (HGI) quantifies the difference in HbA1c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2330615 |
| _version_ | 1797249332653588480 |
|---|---|
| author | Weimeng Cheng Rong Huang Yue Pu Tianyue Li Xue Bao Jianzhou Chen Guannan Li Han Wu Zhonghai Wei |
| author_facet | Weimeng Cheng Rong Huang Yue Pu Tianyue Li Xue Bao Jianzhou Chen Guannan Li Han Wu Zhonghai Wei |
| author_sort | Weimeng Cheng |
| collection | DOAJ |
| description | AbstractBackground A growing number of studies show that people with similar blood glucose levels have different levels of glycosylated haemoglobin (HbA1c), and relying only on HbA1c may lead to clinical decision-making errors. The haemoglobin glycation index (HGI) quantifies the difference in HbA1c among individuals and is strongly linked to the risk of cardiovascular disease. However, the connection between this phenomenon and the poor outcomes of patients with acute decompensated heart failure (ADHF) is currently unknown.Patients and Methods This retrospective, single-centre-based cohort study included 1531 hospitalized patients with ADHF from September 2010 to January 2020. The HGI is calculated from the difference between the observed and predicted HbA1c values [predicted HbA1c = 0.024 × fasting plasma glucose (FPG) (mg/dL)+3.1]. The endpoints examined in the study included all-cause death, cardiovascular (CV) death, and major adverse cardiac events (MACE). We fitted multivariable-adjusted Cox proportional hazard models to investigate the association between the HGI and clinical outcomes.Results During the five-year follow-up, 427 (27.9%) patients died from all causes, 232 (15.6%) from CV death, and 848 (55.4%) from MACE. The restricted cubic spline analysis also showed that the cumulative risk of all-cause and CV deaths decreased linearly with increasing HGI. According to multivariate Cox proportional hazard models, the highest tertile of the HGI was associated with a lower incidence of all-cause and cardiovascular deaths [all-cause death, adjusted hazard ratio (HR): 0.720, 95% confidence interval (CI): 0.563–0.921, p = 0.009; CV death, adjusted HR: 0.619, 95% CI: 0.445–0.861, p = 0.004]. A 1% increase in the HGI was associated with a 12.5% reduction in the risk of all-cause death and a 20.8% reduction in the risk of CV death.Conclusions A high HGI was directly associated with a reduction in all-cause and CV deaths but was not associated with MACE. These findings may be helpful in the management of patients with ADHF. |
| first_indexed | 2024-04-24T20:28:48Z |
| format | Article |
| id | doaj.art-3125043c3d5d46edb0d5652e881510d6 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-24T20:28:48Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-3125043c3d5d46edb0d5652e881510d62024-03-21T23:06:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2330615Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failureWeimeng Cheng0Rong Huang1Yue Pu2Tianyue Li3Xue Bao4Jianzhou Chen5Guannan Li6Han Wu7Zhonghai Wei8Department of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaDepartment of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu, Nanjing, ChinaAbstractBackground A growing number of studies show that people with similar blood glucose levels have different levels of glycosylated haemoglobin (HbA1c), and relying only on HbA1c may lead to clinical decision-making errors. The haemoglobin glycation index (HGI) quantifies the difference in HbA1c among individuals and is strongly linked to the risk of cardiovascular disease. However, the connection between this phenomenon and the poor outcomes of patients with acute decompensated heart failure (ADHF) is currently unknown.Patients and Methods This retrospective, single-centre-based cohort study included 1531 hospitalized patients with ADHF from September 2010 to January 2020. The HGI is calculated from the difference between the observed and predicted HbA1c values [predicted HbA1c = 0.024 × fasting plasma glucose (FPG) (mg/dL)+3.1]. The endpoints examined in the study included all-cause death, cardiovascular (CV) death, and major adverse cardiac events (MACE). We fitted multivariable-adjusted Cox proportional hazard models to investigate the association between the HGI and clinical outcomes.Results During the five-year follow-up, 427 (27.9%) patients died from all causes, 232 (15.6%) from CV death, and 848 (55.4%) from MACE. The restricted cubic spline analysis also showed that the cumulative risk of all-cause and CV deaths decreased linearly with increasing HGI. According to multivariate Cox proportional hazard models, the highest tertile of the HGI was associated with a lower incidence of all-cause and cardiovascular deaths [all-cause death, adjusted hazard ratio (HR): 0.720, 95% confidence interval (CI): 0.563–0.921, p = 0.009; CV death, adjusted HR: 0.619, 95% CI: 0.445–0.861, p = 0.004]. A 1% increase in the HGI was associated with a 12.5% reduction in the risk of all-cause death and a 20.8% reduction in the risk of CV death.Conclusions A high HGI was directly associated with a reduction in all-cause and CV deaths but was not associated with MACE. These findings may be helpful in the management of patients with ADHF.https://www.tandfonline.com/doi/10.1080/07853890.2024.2330615Haemoglobin glycation indexacute decompensated heart failureall-cause deathcardiovascular deathmajor adverse cardiac eventsdiabetes |
| spellingShingle | Weimeng Cheng Rong Huang Yue Pu Tianyue Li Xue Bao Jianzhou Chen Guannan Li Han Wu Zhonghai Wei Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure Annals of Medicine Haemoglobin glycation index acute decompensated heart failure all-cause death cardiovascular death major adverse cardiac events diabetes |
| title | Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure |
| title_full | Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure |
| title_fullStr | Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure |
| title_full_unstemmed | Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure |
| title_short | Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure |
| title_sort | association between the haemoglobin glycation index hgi and clinical outcomes in patients with acute decompensated heart failure |
| topic | Haemoglobin glycation index acute decompensated heart failure all-cause death cardiovascular death major adverse cardiac events diabetes |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2330615 |
| work_keys_str_mv | AT weimengcheng associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT ronghuang associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT yuepu associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT tianyueli associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT xuebao associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT jianzhouchen associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT guannanli associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT hanwu associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure AT zhonghaiwei associationbetweenthehaemoglobinglycationindexhgiandclinicaloutcomesinpatientswithacutedecompensatedheartfailure |