Functional complexity of the Leishmania granuloma and the potential of in silico modelling

Functional complexity of the Leishmania granuloma and the potential of in silico modelling

AbstractIn human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studi...

Full description

Bibliographic Details
Main Authors:	John eMoore, Daniel eMoyo, Lynette eBeattie, Paul eAndrews, Jon eTimmis, Paul eKaye
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-02-01
Series:	Frontiers in Immunology
Subjects:	Granuloma Inflammation Leishmaniasis, Visceral imaging In silico modeling
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00035/full

Similar Items

Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling
by: Daniel Moyo, et al.
Published: (2018-03-01)

Pairing experimentation and computational modelling to understand the role of tissue inducer cells in the development of lymphoid organs
by: Kieran eAlden, et al.
Published: (2012-07-01)

Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
by: Filipe Marques, et al.
Published: (2015-12-01)

CRYOPRESERVATION OF LEISHMANIA DONOVANI PROMASTIGOTES AT -80°C
by: E. Kaneva
Published: (2022-12-01)

An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes
by: Md Anik Ashfaq Khan, et al.
Published: (2020-04-01)

Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum
by: Isadora S. Lima, et al.
Published: (2019-10-01)

Licochalcone a Exhibits Leishmanicidal Activity in vitro and in Experimental Model of Leishmania (Leishmania) Infantum
by: Julia M. Souza, et al.
Published: (2020-12-01)

Cross-protective immunity to Leishmania amazonensis is mediated by CD4+ and CD8+-epitopes of Leishmania donovani Nucleoside Hydrolase terminal domains
by: Dirlei eNico, et al.
Published: (2014-05-01)

Leishmania donovani Nucleoside Hydrolase terminal domains in cross-protective immunotherapy against Leishmania amazonensis murine infection
by: Dirlei eNico, et al.
Published: (2014-06-01)

Canine visceral leishmaniasis in area with recent Leishmania transmission: prevalence, diagnosis, and molecular identification of the infecting species
by: Josiane Valadão Lopes, et al.
Published: (2020-09-01)

A Petri net model of granulomatous inflammation: implications for IL-10 mediated control of Leishmania donovani infection.
by: Luca Albergante, et al.
Published: (2013-01-01)

Leishmania tropica infection in wild and domestic canines
by: G Baneth, et al.
Published: (2014-04-01)

Non-Caseating Granulomas in Skin Biopsies of Leishmania Cases
by: Siyab Ahmad, Nadeem Zafar, Muhammad Owais Qurni, Shabir Ahmad Orakzai, Muhammad Atif Khalil, Wajahat Ahmad Khan
Published: (2023-03-01)

Testicular and seminal evaluation of dogs naturally infected with Leishmania sp.
by: Luanna Soares de Melo Evangelista, et al.
Published: (2019-02-01)

Predictive factors for Leishmania infantum infection in dogs examined at a veterinary teaching hospital in Teresina, State of Piauí, Brazil
by: Marcus Vinicius Gouvêa, et al.
Published: (2016-02-01)

Hepatic granulomas in canine visceral leishmaniasis and clinical status Granulomas hepáticos na leishmaniose visceral canina e classificação clínica
by: J.A.P. Sant’Ana, et al.
Published: (2007-10-01)

Comparison of real-time PCR and conventional PCR for detection of Leishmania (Leishmania) infantum infection: a mini-review
by: M Paiva-Cavalcanti, et al.
Published: (2010-01-01)

Geographic distribution and spatial analysis of Leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic visceral leishmaniasis in Iran: A systematic review
by: M Mohebali, et al.
Published: (2018-01-01)

Cellular Markers of Active Disease and Cure in Different Forms of Leishmania infantum-Induced Disease
by: Laura Botana, et al.
Published: (2018-11-01)

An investigation about the possible role of cattle and goats as reservoir hosts for Leishmania donovani in Bangladesh
by: Mohmmad Zahangir Alam, et al.
Published: (2018-01-01)

Effects of Visceralising Leishmania on the Spleen, Liver, and Bone Marrow: A Pathophysiological Perspective
by: Aikaterini Poulaki, et al.
Published: (2021-04-01)

Histopathological and immunohistochemical study of the gastrointestinal tract from a dog naturally infected with Leishmania (Leishmania) chagasi: a case report
by: F.L. Silva, et al.
Published: (2002-08-01)

Therapeutic success and failure in using miltefosine to treat dogs naturally infected with Leishmania infantum
by: Gustavo Gonçalves, et al.
Published: (2024-02-01)

Place of Serology in the Diagnosis of Zoonotic Leishmaniases With a Focus on Visceral Leishmaniasis Due to Leishmania infantum
by: Maude F. Lévêque, et al.
Published: (2020-02-01)

Granuloma anular perfurante generalizado Generalized perforating granuloma annulare
by: Sérgio Ivan Torres Dornelles, et al.
Published: (2011-04-01)

Vaccination with Formulation of Nanoparticles Loaded with <i>Leishmania amazonensis</i> Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster
by: Marco Antonio Cabrera González, et al.
Published: (2023-01-01)

A Case of Visceral Leishmaniasis at the Child from North Osetia
by: V. V. Lazarev, et al.
Published: (2010-06-01)

Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs
by: Maurício Franco Zanette, et al.
Published: (2014-01-01)

Inflammatory response, parasite load and AgNOR expression in ear skin of symptomatic and asymptomatic Leishmania (Leishmania) chagasi infected dogs
by: Verçosa BLA, et al.
Published: (2011-01-01)

Bionomic aspects of Lutzomyia evansi and Lutzomyia longipalpis, proven vectors of Leishmania infantum in an endemic area of non-ulcerative cutaneous leishmaniasis in Honduras
by: Ángel Mejía, et al.
Published: (2018-01-01)

Presence of amastigotes in the central nervous system of hamsters infected with Leishmania sp. Presença de amastigotas em sistema nervoso central de hamster infectado com Leishmania sp.
by: Elisangela de Oliveira, et al.
Published: (2011-06-01)

Occurrence of low density of <i>Leishmania infantum</i> in sandflies from a new focus of visceral leishmaniasis in northwest of Iran
by: P. Parvizi, et al.
Published: (2013-04-01)

Necrobiotic granuloma: An update
by: Achyut Pokharel, et al.
Published: (2018-01-01)

Vaccines for canine leishmaniasis
by: Clarisa B. Palatnik-De-Sousa
Published: (2012-04-01)

A comparison of molecular markers to detect Lutzomyia longipalpis naturally infected with Leishmania (Leishmania) infantum
by: Kárita Cláudia Freitas-Lidani, et al.
Published: (2014-07-01)

An atypical Toxoplasma gondii genotype in a rural Brazilian dog co-infected with Leishmania (Viannia) braziliensis
by: Rodrigo Costa da Silva, et al.
Published: (2015-04-01)

Spatiotemporal analysis and environmental risk factors of visceral leishmaniasis in an urban setting in São Paulo State, Brazil
by: Luiz E. Prestes-Carneiro, et al.
Published: (2019-05-01)

Spatial and temporal changes in Lutzomyia longipalpis abundance, a Leishmania infantum vector in an urban area in northeastern Argentina
by: Maria Soledad Fernandez, et al.
Published: (2013-11-01)

PF-429242, a Subtilisin Inhibitor, Is Effective in vitro Against Leishmania infantum
by: Patrícia de Almeida Machado, et al.
Published: (2021-01-01)

Leishmania donovani and Cutaneous Leishmaniasis, Sri Lanka
by: H. V. Yamuna D. Siriwardana, et al.
Published: (2007-03-01)