The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis
Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important S...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-04-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1015 |
| _version_ | 1797701241691701248 |
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| author | Elham Nazar Fatemeh Khatami Hiva Saffar Seyed Mohammad Tavangar |
| author_facet | Elham Nazar Fatemeh Khatami Hiva Saffar Seyed Mohammad Tavangar |
| author_sort | Elham Nazar |
| collection | DOAJ |
| description | Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key function both in familial and non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations can have resulted in genetic and epigenetic changes like histone hypermethylation. These properties can lead to succinate-mediated inhibition of α-ketoglutarate-dependent dioxygenases. So hypoxic conditions can generate subsequent neoplastic transformation, and in this review, we are presenting the role of SDHx in several malignancies. |
| first_indexed | 2024-03-12T04:32:37Z |
| format | Article |
| id | doaj.art-31262bde1fae431bad226d20918296cc |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T04:32:37Z |
| publishDate | 2019-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-31262bde1fae431bad226d20918296cc2023-09-03T09:58:58ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072019-04-0113210.18502/ijhoscr.v13i2.692The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in TumorigenesisElham Nazar0Fatemeh Khatami1Hiva Saffar2Seyed Mohammad Tavangar3Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranTransformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key function both in familial and non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations can have resulted in genetic and epigenetic changes like histone hypermethylation. These properties can lead to succinate-mediated inhibition of α-ketoglutarate-dependent dioxygenases. So hypoxic conditions can generate subsequent neoplastic transformation, and in this review, we are presenting the role of SDHx in several malignancies.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1015Succinate dehydrogenases, Tumor, Genetic |
| spellingShingle | Elham Nazar Fatemeh Khatami Hiva Saffar Seyed Mohammad Tavangar The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis International Journal of Hematology-Oncology and Stem Cell Research Succinate dehydrogenases, Tumor, Genetic |
| title | The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis |
| title_full | The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis |
| title_fullStr | The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis |
| title_full_unstemmed | The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis |
| title_short | The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis |
| title_sort | emerging role of succinate dehyrogenase genes sdhx in tumorigenesis |
| topic | Succinate dehydrogenases, Tumor, Genetic |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1015 |
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