Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review
ABSTRACT Objective: To perform a systematic review of randomized controlled trials, evaluating the effect of probiotics, prebiotics or symbiotics supplementation on glycemic and inflammatory control in children with Type 1 Diabetes Mellitus (T1DM). Data source: The Medical Literature Analysis and...
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| Format: | Article |
| Language: | English |
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Sociedade de Pediatria de São Paulo
2024-02-01
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| Series: | Revista Paulista de Pediatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822024000100512&tlng=en |
| _version_ | 1797302329476644864 |
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| author | Luisa Pinheiro Neiva Luiza Correia Lopez Rafaela Orsi Pasiani Mayco José Reinaldi Serra Vera Esteves Vagnozzi Rullo |
| author_facet | Luisa Pinheiro Neiva Luiza Correia Lopez Rafaela Orsi Pasiani Mayco José Reinaldi Serra Vera Esteves Vagnozzi Rullo |
| author_sort | Luisa Pinheiro Neiva |
| collection | DOAJ |
| description | ABSTRACT Objective: To perform a systematic review of randomized controlled trials, evaluating the effect of probiotics, prebiotics or symbiotics supplementation on glycemic and inflammatory control in children with Type 1 Diabetes Mellitus (T1DM). Data source: The Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Clinical Trials, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and Scientific Electronic Library Online (SciELO) databases were searched. Randomized clinical trials of pediatric patients with DM1 using probiotics, prebiotics or symbiotics were included, regardless of year or language of publication. Studies that did not evaluate glycated hemoglobin (HbA1c) were excluded. Metabolic results (HbA1c, total insulin dose and C-peptide) and inflammatory control [interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ)] during probiotic supplementation or similar, related to modification of the intestinal microbiota, were analyzed. PROSPERO ID: CRD42022384485. Data synthesis: Five studies were selected for a systematic review. Regarding metabolic markers, only one of the articles that analyzed HbA1c showed a significant decrease (p=0.03) in the intervention group. One study identified a reduction in the total dose of insulin and increased C-peptide levels. Regarding the evaluation of inflammatory parameters (IL-10, TNF-α, INF-γ), there were no statistical relevant modifications. Conclusions: Current data from the literature were not conclusive in identifying an improvement in glycemic control and did not observe changes in inflammatory parameters with the use of probiotics, prebiotics or symbiotics in pediatric patients with T1DM. |
| first_indexed | 2024-03-07T23:35:15Z |
| format | Article |
| id | doaj.art-312639191760442a9777a1e46af66498 |
| institution | Directory Open Access Journal |
| issn | 1984-0462 |
| language | English |
| last_indexed | 2024-03-07T23:35:15Z |
| publishDate | 2024-02-01 |
| publisher | Sociedade de Pediatria de São Paulo |
| record_format | Article |
| series | Revista Paulista de Pediatria |
| spelling | doaj.art-312639191760442a9777a1e46af664982024-02-20T07:38:17ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-04622024-02-014210.1590/1984-0462/2024/42/2023097Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic reviewLuisa Pinheiro Neivahttps://orcid.org/0000-0002-7829-8615Luiza Correia Lopezhttps://orcid.org/0000-0002-2110-5608Rafaela Orsi Pasianihttps://orcid.org/0000-0002-9947-2141Mayco José Reinaldi Serrahttps://orcid.org/0000-0001-5697-6772Vera Esteves Vagnozzi Rullohttps://orcid.org/0000-0002-4754-6612ABSTRACT Objective: To perform a systematic review of randomized controlled trials, evaluating the effect of probiotics, prebiotics or symbiotics supplementation on glycemic and inflammatory control in children with Type 1 Diabetes Mellitus (T1DM). Data source: The Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Clinical Trials, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and Scientific Electronic Library Online (SciELO) databases were searched. Randomized clinical trials of pediatric patients with DM1 using probiotics, prebiotics or symbiotics were included, regardless of year or language of publication. Studies that did not evaluate glycated hemoglobin (HbA1c) were excluded. Metabolic results (HbA1c, total insulin dose and C-peptide) and inflammatory control [interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ)] during probiotic supplementation or similar, related to modification of the intestinal microbiota, were analyzed. PROSPERO ID: CRD42022384485. Data synthesis: Five studies were selected for a systematic review. Regarding metabolic markers, only one of the articles that analyzed HbA1c showed a significant decrease (p=0.03) in the intervention group. One study identified a reduction in the total dose of insulin and increased C-peptide levels. Regarding the evaluation of inflammatory parameters (IL-10, TNF-α, INF-γ), there were no statistical relevant modifications. Conclusions: Current data from the literature were not conclusive in identifying an improvement in glycemic control and did not observe changes in inflammatory parameters with the use of probiotics, prebiotics or symbiotics in pediatric patients with T1DM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822024000100512&tlng=enGlycated hemoglobin ADiabetes mellitus type 1ProbioticsGlycemic controlCytokines |
| spellingShingle | Luisa Pinheiro Neiva Luiza Correia Lopez Rafaela Orsi Pasiani Mayco José Reinaldi Serra Vera Esteves Vagnozzi Rullo Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review Revista Paulista de Pediatria Glycated hemoglobin A Diabetes mellitus type 1 Probiotics Glycemic control Cytokines |
| title | Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review |
| title_full | Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review |
| title_fullStr | Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review |
| title_full_unstemmed | Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review |
| title_short | Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review |
| title_sort | use of probiotics and similar in pediatric patients with type 1 diabetes mellitus a systematic review |
| topic | Glycated hemoglobin A Diabetes mellitus type 1 Probiotics Glycemic control Cytokines |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822024000100512&tlng=en |
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