The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study
Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a sta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3825 |
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| author | Ana Nieto-Ruiz Estefanía Diéguez Natalia Sepúlveda-Valbuena Florian Herrmann Tomás Cerdó Francisca López-Torrecillas Roser De-Castellar Jesús Jiménez Miguel Pérez-García María T. Miranda Andrés Catena José A. García-Santos Mercedes G. Bermúdez Cristina Campoy |
| author_facet | Ana Nieto-Ruiz Estefanía Diéguez Natalia Sepúlveda-Valbuena Florian Herrmann Tomás Cerdó Francisca López-Torrecillas Roser De-Castellar Jesús Jiménez Miguel Pérez-García María T. Miranda Andrés Catena José A. García-Santos Mercedes G. Bermúdez Cristina Campoy |
| author_sort | Ana Nieto-Ruiz |
| collection | DOAJ |
| description | Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, <i>n</i> = 29) or a bioactive compounds enriched-infant formula (EF, <i>n</i> = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development. |
| first_indexed | 2024-03-10T14:03:43Z |
| format | Article |
| id | doaj.art-312657c7008e4109a01104ec153a7cc6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:03:43Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-312657c7008e4109a01104ec153a7cc62023-11-21T00:50:09ZengMDPI AGNutrients2072-66432020-12-011212382510.3390/nu12123825The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS StudyAna Nieto-Ruiz0Estefanía Diéguez1Natalia Sepúlveda-Valbuena2Florian Herrmann3Tomás Cerdó4Francisca López-Torrecillas5Roser De-Castellar6Jesús Jiménez7Miguel Pérez-García8María T. Miranda9Andrés Catena10José A. García-Santos11Mercedes G. Bermúdez12Cristina Campoy13Department of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainMind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, SpainOrdesa Laboratories, S.L., 08820 Barcelona, SpainOrdesa Laboratories, S.L., 08820 Barcelona, SpainMind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, SpainDepartment of Biostatistics, School of Medicine, University of Granada, 18016 Granada, SpainMind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainAlthough early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, <i>n</i> = 29) or a bioactive compounds enriched-infant formula (EF, <i>n</i> = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.https://www.mdpi.com/2072-6643/12/12/3825infant formulamilk fat globule membranelong-chain polyunsaturated fatty acidsbioactive compoundschildren behaviorbreastfeeding |
| spellingShingle | Ana Nieto-Ruiz Estefanía Diéguez Natalia Sepúlveda-Valbuena Florian Herrmann Tomás Cerdó Francisca López-Torrecillas Roser De-Castellar Jesús Jiménez Miguel Pérez-García María T. Miranda Andrés Catena José A. García-Santos Mercedes G. Bermúdez Cristina Campoy The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study Nutrients infant formula milk fat globule membrane long-chain polyunsaturated fatty acids bioactive compounds children behavior breastfeeding |
| title | The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study |
| title_full | The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study |
| title_fullStr | The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study |
| title_full_unstemmed | The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study |
| title_short | The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study |
| title_sort | effects of an infant formula enriched with milk fat globule membrane long chain polyunsaturated fatty acids and synbiotics on child behavior up to 2 5 years old the cognis study |
| topic | infant formula milk fat globule membrane long-chain polyunsaturated fatty acids bioactive compounds children behavior breastfeeding |
| url | https://www.mdpi.com/2072-6643/12/12/3825 |
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