A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer
CD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/3/232 |
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| author | Antonio Fernando Leis-Filho Patrícia de Faria Lainetti Mayara Simão Franzoni Chiara Palmieri Priscila Emiko Kobayshi Renee Laufer-Amorim Carlos Eduardo Fonseca-Alves |
| author_facet | Antonio Fernando Leis-Filho Patrícia de Faria Lainetti Mayara Simão Franzoni Chiara Palmieri Priscila Emiko Kobayshi Renee Laufer-Amorim Carlos Eduardo Fonseca-Alves |
| author_sort | Antonio Fernando Leis-Filho |
| collection | DOAJ |
| description | CD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publications fitting with the inclusion criteria of this study. Of the 10 manuscripts, 5 demonstrated a direct correlation between CD24 overexpression and patient prognoses. CD24 expression was also associated with PSA relapse (2/5) and tumor progression (1/5). However, the in silico analysis did not validate CD24 as a prognostic factor of human PC. Regarding canine PC, 10 out of 30 normal prostates and 27 out of 40 PC samples were positive for CD24. As in humans, there was no association with overall survival. Overall, our results demonstrated a significant CD24 overexpression in human and canine prostate cancer, although its prognostic value may be questionable. However, tumors overexpressing CD24 may be a reliable model for new target therapies and dogs could be used of a unique preclinical model for these studies. |
| first_indexed | 2024-03-10T12:58:47Z |
| format | Article |
| id | doaj.art-3126fb19e50b471a8c75ea7dcb4d7b45 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T12:58:47Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-3126fb19e50b471a8c75ea7dcb4d7b452023-11-21T11:38:45ZengMDPI AGJournal of Personalized Medicine2075-44262021-03-0111323210.3390/jpm11030232A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate CancerAntonio Fernando Leis-Filho0Patrícia de Faria Lainetti1Mayara Simão Franzoni2Chiara Palmieri3Priscila Emiko Kobayshi4Renee Laufer-Amorim5Carlos Eduardo Fonseca-Alves6Department of Veterinary Surgery and Animal Reproduction, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilDepartment of Veterinary Surgery and Animal Reproduction, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilDepartment of Veterinary Surgery and Animal Reproduction, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilSchool of Veterinary Science, Gatton Campus, The University of Queensland-UQ, Brisbane Qld 4343, AustraliaDepartment of Veterinary Clinic, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilDepartment of Veterinary Clinic, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilDepartment of Veterinary Surgery and Animal Reproduction, Sao Paulo State University-UNESP, Botucatu 18618-681, BrazilCD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publications fitting with the inclusion criteria of this study. Of the 10 manuscripts, 5 demonstrated a direct correlation between CD24 overexpression and patient prognoses. CD24 expression was also associated with PSA relapse (2/5) and tumor progression (1/5). However, the in silico analysis did not validate CD24 as a prognostic factor of human PC. Regarding canine PC, 10 out of 30 normal prostates and 27 out of 40 PC samples were positive for CD24. As in humans, there was no association with overall survival. Overall, our results demonstrated a significant CD24 overexpression in human and canine prostate cancer, although its prognostic value may be questionable. However, tumors overexpressing CD24 may be a reliable model for new target therapies and dogs could be used of a unique preclinical model for these studies.https://www.mdpi.com/2075-4426/11/3/232carcinomaprostateCD24comparative oncologydog |
| spellingShingle | Antonio Fernando Leis-Filho Patrícia de Faria Lainetti Mayara Simão Franzoni Chiara Palmieri Priscila Emiko Kobayshi Renee Laufer-Amorim Carlos Eduardo Fonseca-Alves A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer Journal of Personalized Medicine carcinoma prostate CD24 comparative oncology dog |
| title | A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer |
| title_full | A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer |
| title_fullStr | A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer |
| title_full_unstemmed | A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer |
| title_short | A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer |
| title_sort | comparative in silico analysis of cd24 s prognostic value in human and canine prostate cancer |
| topic | carcinoma prostate CD24 comparative oncology dog |
| url | https://www.mdpi.com/2075-4426/11/3/232 |
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