Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ × SM/J intercross[S]

Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ × SM/J intercross[S]

A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), fou...

Full description

Bibliographic Details
Main Authors:	Magalie S. Leduc, Rachael Hageman Blair, Ricardo A. Verdugo, Shirng-Wern Tsaih, Kenneth Walsh, Gary A. Churchill, Beverly Paigen
Format:	Article
Language:	English
Published:	Elsevier 2012-06-01
Series:	Journal of Lipid Research
Subjects:	high-density lipoprotein cholesterol gene suppression genomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520317090

Similar Items

Mapping genetic loci that regulate lipid levels in a NZB/B1NJ×RF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains
by: Jon E. Wergedal, et al.
Published: (2007-08-01)

Genomic analysis of the appearance of ovarian mast cells in neonatal MRL/MpJ mice.
by: Teppei Nakamura, et al.
Published: (2014-01-01)

Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ*s⃞
by: Zhiguang Su, et al.
Published: (2008-07-01)

Ovarian mast cells migrate toward ovary-fimbria connection in neonatal MRL/MpJ mice.
by: Teppei Nakamura, et al.
Published: (2018-01-01)

Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ × SJL/J inbred mice
by: Apurva K. Srivastava, et al.
Published: (2006-01-01)

Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice
by: Elster Eric A, et al.
Published: (2010-05-01)

Relationship between numerous mast cells and early follicular development in neonatal MRL/MpJ mouse ovaries.
by: Teppei Nakamura, et al.
Published: (2013-01-01)

Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse
by: Jacob G. Kallenbach, et al.
Published: (2022-02-01)

Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population
by: Ron Korstanje, et al.
Published: (2004-05-01)

MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
by: Xueqin Gao, et al.
Published: (2023-01-01)

Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity
by: Amy G. Clark, et al.
Published: (2008-01-01)

Sex-related differences in autoimmune-induced lung lesions in MRL/MpJ-faslpr mice are mediated by the development of mediastinal fat-associated lymphoid clusters
by: Yaser Hosny Ali Elewa, et al.
Published: (2017-07-01)

Hydronephrosis with ureteritis developed in C57BL/6N mice carrying the congenic region derived from MRL/MpJ-type chromosome 11
by: Osamu Ichii, et al.
Published: (2017-02-01)

Intra-articular Delivery of Purified Mesenchymal Stem Cells from C57BL/6 or MRL/MpJ Superhealer Mice Prevents Posttraumatic Arthritis
by: Brian O. Diekman, et al.
Published: (2013-08-01)

Allogeneic Bone Marrow Transplant from MRL/MpJ Super-Healer Mice Does Not Improve Articular Cartilage Repair in the C57Bl/6 Strain.
by: Catherine A Leonard, et al.
Published: (2015-01-01)

Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model
by: Rikang Wang, et al.
Published: (2020-03-01)

Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice
by: Melissa G. Kramer, et al.
Published: (1998-06-01)

Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes
by: Zhiguang Su, et al.
Published: (2010-09-01)

Structural model analysis of multiple quantitative traits.
by: Renhua Li, et al.
Published: (2006-07-01)

An experimental assessment of <it>in silico </it>haplotype association mapping in laboratory mice
by: Stylianou Ioannis M, et al.
Published: (2009-12-01)

Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains
by: Andrew T. Grainger, et al.
Published: (2017-02-01)

Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line
by: Camron D Bryant, et al.
Published: (2012-07-01)

The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol[S]
by: Magalie S. Leduc, et al.
Published: (2011-06-01)

Genetic architecture of nest building in mice LG/J x SM/J
by: Bruno eSauce, et al.
Published: (2012-05-01)

Differences in DBA/1J and DBA/2J reveal lipid QTL geness⃞
by: Ioannis M. Stylianou, et al.
Published: (2008-11-01)

Genetic Dissection of Growth Traits in a Unique Chicken Advanced Intercross Line
by: Yuzhe Wang, et al.
Published: (2020-09-01)

Genetic control of spontaneous arthritis in a four-way advanced intercross line.
by: Laura Mellado Ranea, et al.
Published: (2013-01-01)

Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants
by: Yora Nindita, et al.
Published: (2023-04-01)

Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds.
by: Natalia Makhanova, et al.
Published: (2017-01-01)

Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis
by: Cheryl Ackert-Bicknell, et al.
Published: (2013-04-01)

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.
by: Anna L Tyler, et al.
Published: (2016-02-01)

Machine learning reveals genetic modifiers of the immune microenvironment of cancer
by: Bridget Riley-Gillis, et al.
Published: (2023-09-01)

NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer
by: Cody Plasterer, et al.
Published: (2023-07-01)

Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice1,2
by: Malcolm A. Lyons, et al.
Published: (2003-05-01)

Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis.
by: Jeremy L Peirce, et al.
Published: (2008-04-01)

A new standard genetic map for the laboratory mouse.
by: Cox, A, et al.
Published: (2009)

Estimation of variability, heritability, genetic advance and assessment of frequency distribution for morphological traits in intercross population of maize
by: C. Neelima, C. Sarankumar, M. Sudha, K. N. Ganesan, R. Ravikesavan and N. Senthil
Published: (2020-06-01)

Data on genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains
by: Daniela T. Fuller, et al.
Published: (2020-04-01)

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice
by: Nielsen Merlyn K, et al.
Published: (2005-03-01)

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice
by: Liu Y, et al.
Published: (2016-08-01)