Specific eradication of HIV-1 from infected cultured cells
<p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/7/1/31 |
| _version_ | 1831600862870372352 |
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| author | Levin Aviad Hayouka Zvi Friedler Assaf Loyter Abraham |
| author_facet | Levin Aviad Hayouka Zvi Friedler Assaf Loyter Abraham |
| author_sort | Levin Aviad |
| collection | DOAJ |
| description | <p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.</p> |
| first_indexed | 2024-12-18T14:52:28Z |
| format | Article |
| id | doaj.art-3127d2962bed4d5b8964fed376d9784c |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-18T14:52:28Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-3127d2962bed4d5b8964fed376d9784c2022-12-21T21:04:08ZengBMCAIDS Research and Therapy1742-64052010-08-01713110.1186/1742-6405-7-31Specific eradication of HIV-1 from infected cultured cellsLevin AviadHayouka ZviFriedler AssafLoyter Abraham<p>Abstract</p> <p>A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.</p>http://www.aidsrestherapy.com/content/7/1/31 |
| spellingShingle | Levin Aviad Hayouka Zvi Friedler Assaf Loyter Abraham Specific eradication of HIV-1 from infected cultured cells AIDS Research and Therapy |
| title | Specific eradication of HIV-1 from infected cultured cells |
| title_full | Specific eradication of HIV-1 from infected cultured cells |
| title_fullStr | Specific eradication of HIV-1 from infected cultured cells |
| title_full_unstemmed | Specific eradication of HIV-1 from infected cultured cells |
| title_short | Specific eradication of HIV-1 from infected cultured cells |
| title_sort | specific eradication of hiv 1 from infected cultured cells |
| url | http://www.aidsrestherapy.com/content/7/1/31 |
| work_keys_str_mv | AT levinaviad specificeradicationofhiv1frominfectedculturedcells AT hayoukazvi specificeradicationofhiv1frominfectedculturedcells AT friedlerassaf specificeradicationofhiv1frominfectedculturedcells AT loyterabraham specificeradicationofhiv1frominfectedculturedcells |