In Vivo Fibroblast Activation of Systemic Sarcoidosis: A <sup>68</sup>Ga-FAPI-04 PET/CT Imaging Study
A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent <sup>18</sup>FDG PET/CT and <sup>68</sup>Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology <sup>18</sup>FDG PET/CT. True myocard...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/8/1450 |
| Summary: | A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent <sup>18</sup>FDG PET/CT and <sup>68</sup>Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology <sup>18</sup>FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological uptake. The following <sup>68</sup>Ga-FAPI-04 showed intense heterogeneous uptake in the left ventricular wall, particularly in the septum and apex area, corresponding with the late gadolinium enhancement regions shown by cardiac MR. Intense uptake was also noted in the mediastinal and bilateral hilar lymph nodes. Endomyocardial biopsy demonstrated sarcoidosis. |
|---|---|
| ISSN: | 2075-4418 |