A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification

A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification

Summary: Based on high-throughput transcriptomic sequencing, SNHG3 was among the most highly expressed long noncoding RNAs in calcific aortic valve disease. SNHG3 upregulation was verified in human and mouse calcified aortic valves. Moreover, in vivo and in vitro studies showed SNHG3 silencing marke...

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Bibliographic Details
Main Authors: Long Chen, MD, Hanning Liu, MD, PhD, Cheng Sun, MD, PhD, Jianqiu Pei, PhD, Jun Li, MD, Yue Li, PhD, Ke Wei, MD, PhD, Xiaoyi Wang, MD, Peng Wang, MD, Fangzhou Li, MD, Shujie Gai, MD, PhD, Yan Zhao, MD, Zhe Zheng, MD, PhD
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:JACC: Basic to Translational Science
Subjects:
BMP2 pathway
calcific aortic valve disease
long noncoding RNA
osteoblast differentiation
therapeutic target
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X22002297

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http://www.sciencedirect.com/science/article/pii/S2452302X22002297

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