Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome
ObjectivesMigraine is one of the most frequent clinical manifestations of hypermobile Ehlers-Danlos syndrome (hEDS). The comorbidity between these two diseases has been only partially investigated. We aimed to observe whether neurophysiological alterations described in migraineurs in visual evoked p...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1072785/full |
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| author | Ilaria Maestrini Ilaria Maestrini Lorenzo Rocchi Francesca Puledda Alessandro Viganò Alessandro Viganò Giada Giuliani Tommaso Benedetto Jannini Claudia Celletti Marta Altieri Filippo Camerota Massimiliano Toscano Massimiliano Toscano Vittorio Di Piero Vittorio Di Piero |
| author_facet | Ilaria Maestrini Ilaria Maestrini Lorenzo Rocchi Francesca Puledda Alessandro Viganò Alessandro Viganò Giada Giuliani Tommaso Benedetto Jannini Claudia Celletti Marta Altieri Filippo Camerota Massimiliano Toscano Massimiliano Toscano Vittorio Di Piero Vittorio Di Piero |
| author_sort | Ilaria Maestrini |
| collection | DOAJ |
| description | ObjectivesMigraine is one of the most frequent clinical manifestations of hypermobile Ehlers-Danlos syndrome (hEDS). The comorbidity between these two diseases has been only partially investigated. We aimed to observe whether neurophysiological alterations described in migraineurs in visual evoked potentials (VEPs) were present in hEDS patients with migraine.MethodsWe enrolled 22 hEDS patients with migraine (hEDS) and 22 non-hEDS patients with migraine (MIG), with and without aura (according to ICHD-3), as well as 22 healthy controls (HC). Repetitive pattern reversal (PR)-VEPs were recorded in basal conditions in all participants. During uninterrupted stimulation, 250 cortical responses were recorded (4,000 Hz sample rate) and divided into epochs of 300 ms after the stimulus. Cerebral responses were divided into five blocks. The habituation was calculated as the slope interpolating the amplitudes in each block, for both the N75-P100 and P100-N145 components of PR-VEP.ResultsWe observed a significant habituation deficit of the P100-N145 component of PR-VEP in hEDS compared to HC (p = 0.002), unexpectedly more pronounced than in MIG. We observed only a slight habituation deficit of N75-P100 in hEDS, with a slope degree that was intermediate between MIG and HC.DiscussionhEDS patients with migraine presented an interictal habituation deficit of both VEPs components like MIG. Pathophysiological aspects underlying the pathology could account for the peculiar pattern of habituation in hEDS patients with migraine characterized by a pronounced habituation deficit in the P100-N145 component and a less clear-cut habituation deficit in the N75-P100 component with respect to MIG. |
| first_indexed | 2024-04-10T05:12:26Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T05:12:26Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-312bf00e01514ba1ae619010a07477b92023-03-09T05:56:53ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.10727851072785Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndromeIlaria Maestrini0Ilaria Maestrini1Lorenzo Rocchi2Francesca Puledda3Alessandro Viganò4Alessandro Viganò5Giada Giuliani6Tommaso Benedetto Jannini7Claudia Celletti8Marta Altieri9Filippo Camerota10Massimiliano Toscano11Massimiliano Toscano12Vittorio Di Piero13Vittorio Di Piero14Department of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, ItalyHeadache Group, Wolfson Centre for Age-Related Diseases (CARD), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United KingdomDepartment of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milan, ItalyDepartment of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyPhysical Medicine and Rehabilitation Division, Umberto I Hospital, Rome, ItalyDepartment of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyPhysical Medicine and Rehabilitation Division, Umberto I Hospital, Rome, ItalyDepartment of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyDepartment of Neurology, Fatebenefratelli Hospital - Gemelli Isola, Rome, ItalyDepartment of Human Neurosciences, Headache Centre, “Sapienza” University of Rome, Rome, ItalyUniversity Consortium for Adaptive Disorders and Head Pain (UCADH), Pavia, ItalyObjectivesMigraine is one of the most frequent clinical manifestations of hypermobile Ehlers-Danlos syndrome (hEDS). The comorbidity between these two diseases has been only partially investigated. We aimed to observe whether neurophysiological alterations described in migraineurs in visual evoked potentials (VEPs) were present in hEDS patients with migraine.MethodsWe enrolled 22 hEDS patients with migraine (hEDS) and 22 non-hEDS patients with migraine (MIG), with and without aura (according to ICHD-3), as well as 22 healthy controls (HC). Repetitive pattern reversal (PR)-VEPs were recorded in basal conditions in all participants. During uninterrupted stimulation, 250 cortical responses were recorded (4,000 Hz sample rate) and divided into epochs of 300 ms after the stimulus. Cerebral responses were divided into five blocks. The habituation was calculated as the slope interpolating the amplitudes in each block, for both the N75-P100 and P100-N145 components of PR-VEP.ResultsWe observed a significant habituation deficit of the P100-N145 component of PR-VEP in hEDS compared to HC (p = 0.002), unexpectedly more pronounced than in MIG. We observed only a slight habituation deficit of N75-P100 in hEDS, with a slope degree that was intermediate between MIG and HC.DiscussionhEDS patients with migraine presented an interictal habituation deficit of both VEPs components like MIG. Pathophysiological aspects underlying the pathology could account for the peculiar pattern of habituation in hEDS patients with migraine characterized by a pronounced habituation deficit in the P100-N145 component and a less clear-cut habituation deficit in the N75-P100 component with respect to MIG.https://www.frontiersin.org/articles/10.3389/fneur.2023.1072785/fullEhlers-Danlos syndromemigraineneurophysiologyvisual evoked potential (VEP)habituation deficit |
| spellingShingle | Ilaria Maestrini Ilaria Maestrini Lorenzo Rocchi Francesca Puledda Alessandro Viganò Alessandro Viganò Giada Giuliani Tommaso Benedetto Jannini Claudia Celletti Marta Altieri Filippo Camerota Massimiliano Toscano Massimiliano Toscano Vittorio Di Piero Vittorio Di Piero Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome Frontiers in Neurology Ehlers-Danlos syndrome migraine neurophysiology visual evoked potential (VEP) habituation deficit |
| title | Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome |
| title_full | Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome |
| title_fullStr | Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome |
| title_full_unstemmed | Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome |
| title_short | Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome |
| title_sort | habituation deficit of visual evoked potentials in migraine patients with hypermobile ehlers danlos syndrome |
| topic | Ehlers-Danlos syndrome migraine neurophysiology visual evoked potential (VEP) habituation deficit |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1072785/full |
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