Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy
Molecular oleogels have the potential to be used as materials in healthcare applications. However, their design and synthesis are complex, thus requiring simple and effective methods for their preparation. This paper reports on alkylanilides that are low molecular-weight organogelators, which when a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/9/717 |
| _version_ | 1827726000541138944 |
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| author | Yutaka Ohsedo |
| author_facet | Yutaka Ohsedo |
| author_sort | Yutaka Ohsedo |
| collection | DOAJ |
| description | Molecular oleogels have the potential to be used as materials in healthcare applications. However, their design and synthesis are complex, thus requiring simple and effective methods for their preparation. This paper reports on alkylanilides that are low molecular-weight organogelators, which when appropriately mixed with different alkyl chain lengths could result in the formation of mixed molecular gels that exhibit excellent gel-forming ability and mechanical properties. In addition, the single and mixed molecular organogel systems were found to be applicable as single and mixed molecular oleogel systems capable of gelling oils such as olive oil and squalane. This has been found to be true, especially in molecular oleogel systems consisting of squalane, which is used as solvents in healthcare. The mixed squalene-molecular oleogel systems showed an increase in the critical (minimum) gelation concentration from 1.0 to 0.1 wt.% in the single system and an improvement in the thixotropic behavior recovery time. The thixotropic behavior of the molecular oleogels in the mixed system was quantitatively evaluated through dynamic viscoelasticity measurements; however, it was not observed for the single-system molecular oleogels. Scanning electron microscopy of the xerogels suggested that this behavior is related to the qualitative improvement of the network owing to the refinement of the mesh structure. These mixed molecular oleogels, composed of alkylanilides displaying such thixotropic behavior, could be used as candidates for ointment-base materials in the healthcare field. |
| first_indexed | 2024-03-10T22:44:06Z |
| format | Article |
| id | doaj.art-312cc0fb5fd1419ab8a0bf3a71a5334f |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T22:44:06Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-312cc0fb5fd1419ab8a0bf3a71a5334f2023-11-19T10:50:50ZengMDPI AGGels2310-28612023-09-019971710.3390/gels9090717Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing StrategyYutaka Ohsedo0Division of Engineering, Faculty of Engineering, Nara Women’s University, Kitauoyahigashi-Machi, Nara 630-8506, JapanMolecular oleogels have the potential to be used as materials in healthcare applications. However, their design and synthesis are complex, thus requiring simple and effective methods for their preparation. This paper reports on alkylanilides that are low molecular-weight organogelators, which when appropriately mixed with different alkyl chain lengths could result in the formation of mixed molecular gels that exhibit excellent gel-forming ability and mechanical properties. In addition, the single and mixed molecular organogel systems were found to be applicable as single and mixed molecular oleogel systems capable of gelling oils such as olive oil and squalane. This has been found to be true, especially in molecular oleogel systems consisting of squalane, which is used as solvents in healthcare. The mixed squalene-molecular oleogel systems showed an increase in the critical (minimum) gelation concentration from 1.0 to 0.1 wt.% in the single system and an improvement in the thixotropic behavior recovery time. The thixotropic behavior of the molecular oleogels in the mixed system was quantitatively evaluated through dynamic viscoelasticity measurements; however, it was not observed for the single-system molecular oleogels. Scanning electron microscopy of the xerogels suggested that this behavior is related to the qualitative improvement of the network owing to the refinement of the mesh structure. These mixed molecular oleogels, composed of alkylanilides displaying such thixotropic behavior, could be used as candidates for ointment-base materials in the healthcare field.https://www.mdpi.com/2310-2861/9/9/717alkylanilideslow-molecular-weight organogelatorsmixed molecular gelsoleogelsthixotropic behavior |
| spellingShingle | Yutaka Ohsedo Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy Gels alkylanilides low-molecular-weight organogelators mixed molecular gels oleogels thixotropic behavior |
| title | Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy |
| title_full | Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy |
| title_fullStr | Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy |
| title_full_unstemmed | Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy |
| title_short | Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy |
| title_sort | development of thixotropic molecular oleogels comprising alkylanilide gelators by using a mixing strategy |
| topic | alkylanilides low-molecular-weight organogelators mixed molecular gels oleogels thixotropic behavior |
| url | https://www.mdpi.com/2310-2861/9/9/717 |
| work_keys_str_mv | AT yutakaohsedo developmentofthixotropicmolecularoleogelscomprisingalkylanilidegelatorsbyusingamixingstrategy |