Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity
Background: Air pollution exposure has been shown to increase the risk of obesity and metabolic dysfunction in animal models and human studies. However, the metabolic pathways altered by air pollution exposure are unclear, especially in adolescents and young adults who are at a critical period in th...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019312553 |
| _version_ | 1818160320900759552 |
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| author | Zhanghua Chen Christopher B. Newgard Jeniffer S. Kim Olga IIkayeva Tanya L. Alderete Duncan C. Thomas Kiros Berhane Carrie Breton Leda Chatzi Theresa M. Bastain Rob McConnell Edward Avol Fred Lurmann Michael J. Muehlbauer Elizabeth R. Hauser Frank D. Gilliland |
| author_facet | Zhanghua Chen Christopher B. Newgard Jeniffer S. Kim Olga IIkayeva Tanya L. Alderete Duncan C. Thomas Kiros Berhane Carrie Breton Leda Chatzi Theresa M. Bastain Rob McConnell Edward Avol Fred Lurmann Michael J. Muehlbauer Elizabeth R. Hauser Frank D. Gilliland |
| author_sort | Zhanghua Chen |
| collection | DOAJ |
| description | Background: Air pollution exposure has been shown to increase the risk of obesity and metabolic dysfunction in animal models and human studies. However, the metabolic pathways altered by air pollution exposure are unclear, especially in adolescents and young adults who are at a critical period in the development of cardio-metabolic diseases. Objectives: The aim of this study was to examine the associations between air pollution exposure and indices of fatty acid and amino acid metabolism. Methods: A total of 173 young adults (18–23 years) from eight Children's Health Study (CHS) Southern California communities were examined from 2014 to 2018. Near-roadway air pollution (NRAP) exposure (freeway and non-freeway) and regional air pollution exposure (nitrogen dioxide, ozone and particulate matter) during one year before the study visit were estimated based on participants' residential addresses. Serum concentrations of 64 targeted metabolites including amino acids, acylcarnitines, non-esterified fatty acid (NEFA) and glycerol were measured in fasting serum samples. Principal component analysis of metabolites was performed to identify metabolite clusters that represent key metabolic pathways. Mixed effects models were used to analyze the associations of air pollution exposure with metabolomic principal component (PC) scores and individual metabolite concentrations adjusting for potential confounders. Results: Higher lagged one-year averaged non-freeway NRAP exposure was associated with higher concentrations of NEFA oxidation byproducts and higher NEFA-related PC score (all p's ≤ 0.038). The effect sizes were larger among obese individuals (interaction p = 0.047). Among females, higher freeway NRAP exposure was also associated with a higher NEFA-related PC score (p = 0.042). Among all participants, higher freeway NRAP exposure was associated with a lower PC score for lower concentrations of short- and median-chain acylcarnitines (p = 0.044). Conclusions: Results of this study indicate that NRAP exposure is associated with altered fatty acid metabolism, which could contribute to the metabolic perturbation in obese youth. Keywords: Traffic, Air pollution, Obesity, Metabolic diseases, Metabolomics |
| first_indexed | 2024-12-11T16:00:01Z |
| format | Article |
| id | doaj.art-312edfe6a1f04713a80f706425854150 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-11T16:00:01Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-312edfe6a1f04713a80f7064258541502022-12-22T00:59:20ZengElsevierEnvironment International0160-41202019-09-01130Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesityZhanghua Chen0Christopher B. Newgard1Jeniffer S. Kim2Olga IIkayeva3Tanya L. Alderete4Duncan C. Thomas5Kiros Berhane6Carrie Breton7Leda Chatzi8Theresa M. Bastain9Rob McConnell10Edward Avol11Fred Lurmann12Michael J. Muehlbauer13Elizabeth R. Hauser14Frank D. Gilliland15Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; Corresponding author at: Southern California Environmental Health Sciences Center, Department of Preventive Medicine, University of Southern California, Keck School of Medicine of USC, 2001 N. Soto Street #320F, Los Angeles, CA 90032, USA.Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center Durham, NC, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center Durham, NC, USADepartment of Integrative Physiology, University of Colorado at Boulder, Boulder, CO, USADivision of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USASonoma Technology, Inc., Petaluma, CA, USADuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center Durham, NC, USADuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center Durham, NC, USADivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USABackground: Air pollution exposure has been shown to increase the risk of obesity and metabolic dysfunction in animal models and human studies. However, the metabolic pathways altered by air pollution exposure are unclear, especially in adolescents and young adults who are at a critical period in the development of cardio-metabolic diseases. Objectives: The aim of this study was to examine the associations between air pollution exposure and indices of fatty acid and amino acid metabolism. Methods: A total of 173 young adults (18–23 years) from eight Children's Health Study (CHS) Southern California communities were examined from 2014 to 2018. Near-roadway air pollution (NRAP) exposure (freeway and non-freeway) and regional air pollution exposure (nitrogen dioxide, ozone and particulate matter) during one year before the study visit were estimated based on participants' residential addresses. Serum concentrations of 64 targeted metabolites including amino acids, acylcarnitines, non-esterified fatty acid (NEFA) and glycerol were measured in fasting serum samples. Principal component analysis of metabolites was performed to identify metabolite clusters that represent key metabolic pathways. Mixed effects models were used to analyze the associations of air pollution exposure with metabolomic principal component (PC) scores and individual metabolite concentrations adjusting for potential confounders. Results: Higher lagged one-year averaged non-freeway NRAP exposure was associated with higher concentrations of NEFA oxidation byproducts and higher NEFA-related PC score (all p's ≤ 0.038). The effect sizes were larger among obese individuals (interaction p = 0.047). Among females, higher freeway NRAP exposure was also associated with a higher NEFA-related PC score (p = 0.042). Among all participants, higher freeway NRAP exposure was associated with a lower PC score for lower concentrations of short- and median-chain acylcarnitines (p = 0.044). Conclusions: Results of this study indicate that NRAP exposure is associated with altered fatty acid metabolism, which could contribute to the metabolic perturbation in obese youth. Keywords: Traffic, Air pollution, Obesity, Metabolic diseases, Metabolomicshttp://www.sciencedirect.com/science/article/pii/S0160412019312553 |
| spellingShingle | Zhanghua Chen Christopher B. Newgard Jeniffer S. Kim Olga IIkayeva Tanya L. Alderete Duncan C. Thomas Kiros Berhane Carrie Breton Leda Chatzi Theresa M. Bastain Rob McConnell Edward Avol Fred Lurmann Michael J. Muehlbauer Elizabeth R. Hauser Frank D. Gilliland Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity Environment International |
| title | Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity |
| title_full | Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity |
| title_fullStr | Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity |
| title_full_unstemmed | Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity |
| title_short | Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults – The interplay with obesity |
| title_sort | near roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults the interplay with obesity |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019312553 |
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