Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia
Background: Although cerebellar morphological involvement has been increasingly recognized in autism spectrum disorder (ASD) and schizophrenia (SZ), the extent to which there are morphological differences between them has not been definitively quantified. Furthermore, although previous studies have...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174321000458 |
| _version_ | 1818606365812195328 |
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| author | Chie Morimoto Yuko Nakamura Hitoshi Kuwabara Osamu Abe Kiyoto Kasai Hidenori Yamasue Shinsuke Koike |
| author_facet | Chie Morimoto Yuko Nakamura Hitoshi Kuwabara Osamu Abe Kiyoto Kasai Hidenori Yamasue Shinsuke Koike |
| author_sort | Chie Morimoto |
| collection | DOAJ |
| description | Background: Although cerebellar morphological involvement has been increasingly recognized in autism spectrum disorder (ASD) and schizophrenia (SZ), the extent to which there are morphological differences between them has not been definitively quantified. Furthermore, although previous studies have demonstrated increased anatomical cerebellocerebral correlations in both conditions, differences between their associations have not been well characterized. Methods: We compared cerebellar volume between males with ASD (n = 31), males with SZ (n = 28), and typically developing males (n = 49). A total of 31 cerebellar subregions were investigated with the cerebellum segmented into their constituent lobules, in gray matter (GM) and white matter (WM) separately. Additionally, structural correlations with the contralateral cerebrum were analyzed for each cerebellar lobule. Results: We found significantly larger WM volume in the bilateral lobules VI and Crus I in the ASD group than in other groups. While WM or GM volumes of these right lobules had positive associations with ASD symptoms, there was a negative association between GM volume of the right Crus I and SZ symptoms. We further observed, in the ASD group specifically, significant correlations between WM of the right lobule VI and WM of the left frontal pole (r = 0.67) and between GM of the right lobule VI and the left caudate (r = 0.60). Conclusions: Our findings support evidence that cerebellar morphology is involved in ASD and SZ with different mechanisms. Furthermore, this study showed that these biological differences require consideration when determining diagnostic criteria and treatment for these disorders. |
| first_indexed | 2024-12-16T14:09:42Z |
| format | Article |
| id | doaj.art-312f26364335432c812bc3090e9d3bec |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2024-12-16T14:09:42Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-312f26364335432c812bc3090e9d3bec2022-12-21T22:28:48ZengElsevierBiological Psychiatry Global Open Science2667-17432021-09-0113219228Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and SchizophreniaChie Morimoto0Yuko Nakamura1Hitoshi Kuwabara2Osamu Abe3Kiyoto Kasai4Hidenori Yamasue5Shinsuke Koike6Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, JapanUTokyo Center for Integrative Science of Human Behaviour, Graduate School of Art and Sciences, University of Tokyo, Tokyo, JapanDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, JapanDepartment of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Center for Evolutionary Cognitive Science, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan; International Research Center for Neurointelligence, University of Tokyo Institutes for Advanced Study, University of Tokyo, Tokyo, Japan; UTokyo Institute for Diversity and Adaptation of Human Mind, University of Tokyo, Tokyo, JapanDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, JapanUTokyo Center for Integrative Science of Human Behaviour, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan; Center for Evolutionary Cognitive Science, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan; International Research Center for Neurointelligence, University of Tokyo Institutes for Advanced Study, University of Tokyo, Tokyo, Japan; UTokyo Institute for Diversity and Adaptation of Human Mind, University of Tokyo, Tokyo, Japan; Address correspondence to Shinsuke Koike, M.D., Ph.D.Background: Although cerebellar morphological involvement has been increasingly recognized in autism spectrum disorder (ASD) and schizophrenia (SZ), the extent to which there are morphological differences between them has not been definitively quantified. Furthermore, although previous studies have demonstrated increased anatomical cerebellocerebral correlations in both conditions, differences between their associations have not been well characterized. Methods: We compared cerebellar volume between males with ASD (n = 31), males with SZ (n = 28), and typically developing males (n = 49). A total of 31 cerebellar subregions were investigated with the cerebellum segmented into their constituent lobules, in gray matter (GM) and white matter (WM) separately. Additionally, structural correlations with the contralateral cerebrum were analyzed for each cerebellar lobule. Results: We found significantly larger WM volume in the bilateral lobules VI and Crus I in the ASD group than in other groups. While WM or GM volumes of these right lobules had positive associations with ASD symptoms, there was a negative association between GM volume of the right Crus I and SZ symptoms. We further observed, in the ASD group specifically, significant correlations between WM of the right lobule VI and WM of the left frontal pole (r = 0.67) and between GM of the right lobule VI and the left caudate (r = 0.60). Conclusions: Our findings support evidence that cerebellar morphology is involved in ASD and SZ with different mechanisms. Furthermore, this study showed that these biological differences require consideration when determining diagnostic criteria and treatment for these disorders.http://www.sciencedirect.com/science/article/pii/S2667174321000458Autism spectrum disorderCerebellocerebral structureCerebellumMRISchizophreniaStructural neuroimage |
| spellingShingle | Chie Morimoto Yuko Nakamura Hitoshi Kuwabara Osamu Abe Kiyoto Kasai Hidenori Yamasue Shinsuke Koike Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia Biological Psychiatry Global Open Science Autism spectrum disorder Cerebellocerebral structure Cerebellum MRI Schizophrenia Structural neuroimage |
| title | Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia |
| title_full | Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia |
| title_fullStr | Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia |
| title_full_unstemmed | Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia |
| title_short | Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia |
| title_sort | unique morphometric features of the cerebellum and cerebellocerebral structural correlation between autism spectrum disorder and schizophrenia |
| topic | Autism spectrum disorder Cerebellocerebral structure Cerebellum MRI Schizophrenia Structural neuroimage |
| url | http://www.sciencedirect.com/science/article/pii/S2667174321000458 |
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