The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing
Highlights: • Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. • Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as di...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2022-06-01
|
| Series: | Folia Medica Indonesiana |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/FMI/article/view/25212 |
| _version_ | 1818237095007748096 |
|---|---|
| author | Herry Wibowo Prihartini Widiyanti |
| author_facet | Herry Wibowo Prihartini Widiyanti |
| author_sort | Herry Wibowo |
| collection | DOAJ |
| description | Highlights:
• Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures.
• Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing.
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, are standard treatments to relieve pain associated with bone fractures. The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. Previous studies mentioned that intake of NSAIDs (sodium diclofenac) could inhibit the bone healing process. This study examined the effect of diclofenac sodium intake on callus formation in fracture healing. In this study, thirty-six rats (Rattus Norvegicus) with fractures were used and divided into two groups, namely 18 rats for the control and 18 rats for the treatment group. In the treatment group, each rat was given 1.8 mg sodium diclofenac/150 grams of body weight per day. In the control group, each rat was given CMC-Na 0.5% with equal volume as diclofenac sodium in the treatment group. After 28 days, all the rats were stunned until dead, and the diameter and strength of their calluses were measured. In the treatment group with diclofenac sodium1.8 mg/ 150 grams BW/ 28 days after the tibia bone callus was pressed using the Shimadzu tool, the lowest callus strength was found to be 56.500 N, and the highest callus strength was 59.000 N. The lowest callus diameter in the treatment group was 4 mm, the highest was 5 mm. In the control group, the lowest callus strength was 76 N, and the highest callus strength was 77 N. The lowest callus diameter in the control group was 6 mm, and the highest was 8 mm. The strongest callus in the treatment group was found in the sixth observation, with a value of 59 N and a diameter of 4 mm. In the control group, the highest callus strength was 77 N, with a diameter of 7-8 mm. These measurements were found on the 5th, 7th, 8th, 9th, 16th, and 17th observations. Diclofenac sodium with a dose of 1.8 mg/150 grams of body weight could decrease the callus quality parameters, such as callus strength and diameter on fracture healing. |
| first_indexed | 2024-12-12T12:20:18Z |
| format | Article |
| id | doaj.art-312f9db36870447cb08b05cdeb9b5a77 |
| institution | Directory Open Access Journal |
| issn | 2355-8393 2599-056X |
| language | English |
| last_indexed | 2024-12-12T12:20:18Z |
| publishDate | 2022-06-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Folia Medica Indonesiana |
| spelling | doaj.art-312f9db36870447cb08b05cdeb9b5a772022-12-22T00:24:41ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2022-06-0158210811210.20473/fmi.v58i2.2521220650The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture HealingHerry Wibowo0https://orcid.org/0000-0001-9320-4317Prihartini Widiyanti1https://orcid.org/0000-0002-5636-5100Physiology Laboratory, Department of Biomedicine, Faculty of Medicine, Universitas Surabaya, IndonesiaBiomedical Engineering Study Program, Department of Physics, Faculty of Science and Technology, Universitas Airlangga/ Institute of Tropical Disease, Universitas Airlangga, Surabaya, IndonesiaHighlights: • Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. • Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, are standard treatments to relieve pain associated with bone fractures. The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. Previous studies mentioned that intake of NSAIDs (sodium diclofenac) could inhibit the bone healing process. This study examined the effect of diclofenac sodium intake on callus formation in fracture healing. In this study, thirty-six rats (Rattus Norvegicus) with fractures were used and divided into two groups, namely 18 rats for the control and 18 rats for the treatment group. In the treatment group, each rat was given 1.8 mg sodium diclofenac/150 grams of body weight per day. In the control group, each rat was given CMC-Na 0.5% with equal volume as diclofenac sodium in the treatment group. After 28 days, all the rats were stunned until dead, and the diameter and strength of their calluses were measured. In the treatment group with diclofenac sodium1.8 mg/ 150 grams BW/ 28 days after the tibia bone callus was pressed using the Shimadzu tool, the lowest callus strength was found to be 56.500 N, and the highest callus strength was 59.000 N. The lowest callus diameter in the treatment group was 4 mm, the highest was 5 mm. In the control group, the lowest callus strength was 76 N, and the highest callus strength was 77 N. The lowest callus diameter in the control group was 6 mm, and the highest was 8 mm. The strongest callus in the treatment group was found in the sixth observation, with a value of 59 N and a diameter of 4 mm. In the control group, the highest callus strength was 77 N, with a diameter of 7-8 mm. These measurements were found on the 5th, 7th, 8th, 9th, 16th, and 17th observations. Diclofenac sodium with a dose of 1.8 mg/150 grams of body weight could decrease the callus quality parameters, such as callus strength and diameter on fracture healing.https://e-journal.unair.ac.id/FMI/article/view/25212bone fracturesodium diclofenacrattus norvegicuscallus strengthcallus diameter |
| spellingShingle | Herry Wibowo Prihartini Widiyanti The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing Folia Medica Indonesiana bone fracture sodium diclofenac rattus norvegicus callus strength callus diameter |
| title | The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing |
| title_full | The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing |
| title_fullStr | The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing |
| title_full_unstemmed | The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing |
| title_short | The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing |
| title_sort | effect of diclofenac sodium on callus formation in white male rat rattus norvegicus cruris fracture healing |
| topic | bone fracture sodium diclofenac rattus norvegicus callus strength callus diameter |
| url | https://e-journal.unair.ac.id/FMI/article/view/25212 |
| work_keys_str_mv | AT herrywibowo theeffectofdiclofenacsodiumoncallusformationinwhitemaleratrattusnorvegicuscrurisfracturehealing AT prihartiniwidiyanti theeffectofdiclofenacsodiumoncallusformationinwhitemaleratrattusnorvegicuscrurisfracturehealing AT herrywibowo effectofdiclofenacsodiumoncallusformationinwhitemaleratrattusnorvegicuscrurisfracturehealing AT prihartiniwidiyanti effectofdiclofenacsodiumoncallusformationinwhitemaleratrattusnorvegicuscrurisfracturehealing |