Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv
Eucommia ulmoides Oliv. (EU) is an herb with variety of pharmacological activities. As the demand for EU as a medical source increases, its limited availability is becoming an urgent problem. The bark of EU—Eucommia cortex (EC)—was the main medicinal part of EU, whose yield has been too low to meet...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222006207 |
| _version_ | 1811304771202580480 |
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| author | Xin Dong Jie Liu Shu Guo Fan Yang Ren Bu Jingkun Lu Peifeng Xue |
| author_facet | Xin Dong Jie Liu Shu Guo Fan Yang Ren Bu Jingkun Lu Peifeng Xue |
| author_sort | Xin Dong |
| collection | DOAJ |
| description | Eucommia ulmoides Oliv. (EU) is an herb with variety of pharmacological activities. As the demand for EU as a medical source increases, its limited availability is becoming an urgent problem. The bark of EU—Eucommia cortex (EC)—was the main medicinal part of EU, whose yield has been too low to meet market requirements. The EU leaves—Eucommiae folium (EF)—obtained easily from the trees, traditionally considered less valuable than the EU bark. This study compared chemical components and metabolic regulations in different parts of EU using metabolomics to explore the potential for alternative medical sources of EU. The results demonstrated that the composition of EC differs slightly from the composition of EF, and there are some differences in the content of individual ingredients between EC and EF. Combined pharmacodynamic/metabolomics analysis showed that both EC and EF could improve the bone metabolism markers and trabecular microarchitecture of ovariectomized rats mainly by intervening in amino acid metabolism. Our data suggest that EF is a potential alternative medicinal option when EU resources are scarce, and this study provides a mechanistic framework for the benefits of EF in osteoporosis disease. |
| first_indexed | 2024-04-13T08:13:24Z |
| format | Article |
| id | doaj.art-3130a569f09d42ca8361e3174c5a916e |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-13T08:13:24Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-3130a569f09d42ca8361e3174c5a916e2022-12-22T02:54:53ZengElsevierArabian Journal of Chemistry1878-53522022-12-011512104304Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides OlivXin Dong0Jie Liu1Shu Guo2Fan Yang3Ren Bu4Jingkun Lu5Peifeng Xue6School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR China; Inner Mongolia Key Laboratory of Plant Stress Physiology and Molecular Biology, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR ChinaSchool of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR China; Corresponding author.Eucommia ulmoides Oliv. (EU) is an herb with variety of pharmacological activities. As the demand for EU as a medical source increases, its limited availability is becoming an urgent problem. The bark of EU—Eucommia cortex (EC)—was the main medicinal part of EU, whose yield has been too low to meet market requirements. The EU leaves—Eucommiae folium (EF)—obtained easily from the trees, traditionally considered less valuable than the EU bark. This study compared chemical components and metabolic regulations in different parts of EU using metabolomics to explore the potential for alternative medical sources of EU. The results demonstrated that the composition of EC differs slightly from the composition of EF, and there are some differences in the content of individual ingredients between EC and EF. Combined pharmacodynamic/metabolomics analysis showed that both EC and EF could improve the bone metabolism markers and trabecular microarchitecture of ovariectomized rats mainly by intervening in amino acid metabolism. Our data suggest that EF is a potential alternative medicinal option when EU resources are scarce, and this study provides a mechanistic framework for the benefits of EF in osteoporosis disease.http://www.sciencedirect.com/science/article/pii/S1878535222006207Chemical componentsMetabolic regulationsEucommia cortexEucommiae foliumMetabolomics comparison |
| spellingShingle | Xin Dong Jie Liu Shu Guo Fan Yang Ren Bu Jingkun Lu Peifeng Xue Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv Arabian Journal of Chemistry Chemical components Metabolic regulations Eucommia cortex Eucommiae folium Metabolomics comparison |
| title | Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv |
| title_full | Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv |
| title_fullStr | Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv |
| title_full_unstemmed | Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv |
| title_short | Metabolomics comparison of chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv |
| title_sort | metabolomics comparison of chemical components and metabolic regulations in different parts of eucommia ulmoides oliv |
| topic | Chemical components Metabolic regulations Eucommia cortex Eucommiae folium Metabolomics comparison |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222006207 |
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