Application of nanomaterials in diagnosis and treatment of glioblastoma
Diagnosing and treating glioblastoma patients is currently hindered by several obstacles, such as tumor heterogeneity, the blood-brain barrier, tumor complexity, drug efflux pumps, and tumor immune escape mechanisms. Combining multiple methods can increase benefits against these challenges. For exam...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1063152/full |
| _version_ | 1811186199115595776 |
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| author | Shuangqi Yu Shuangqi Yu Lijie Chen Hongyu Xu Hongyu Xu Shengrong Long Shengrong Long Jiazhi Jiang Jiazhi Jiang Wei Wei Wei Wei Xing Niu Xiang Li Xiang Li |
| author_facet | Shuangqi Yu Shuangqi Yu Lijie Chen Hongyu Xu Hongyu Xu Shengrong Long Shengrong Long Jiazhi Jiang Jiazhi Jiang Wei Wei Wei Wei Xing Niu Xiang Li Xiang Li |
| author_sort | Shuangqi Yu |
| collection | DOAJ |
| description | Diagnosing and treating glioblastoma patients is currently hindered by several obstacles, such as tumor heterogeneity, the blood-brain barrier, tumor complexity, drug efflux pumps, and tumor immune escape mechanisms. Combining multiple methods can increase benefits against these challenges. For example, nanomaterials can improve the curative effect of glioblastoma treatments, and the synergistic combination of different drugs can markedly reduce their side effects. In this review, we discuss the progression and main issues regarding glioblastoma diagnosis and treatment, the classification of nanomaterials, and the delivery mechanisms of nanomedicines. We also examine tumor targeting and promising nano-diagnosis or treatment principles based on nanomedicine. We also summarize the progress made on the advanced application of combined nanomaterial-based diagnosis and treatment tools and discuss their clinical prospects. This review aims to provide a better understanding of nano-drug combinations, nano-diagnosis, and treatment options for glioblastoma, as well as insights for developing new tools. |
| first_indexed | 2024-04-11T13:42:40Z |
| format | Article |
| id | doaj.art-31316699671b49f7ad79473d956354c9 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T13:42:40Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-31316699671b49f7ad79473d956354c92022-12-22T04:21:12ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-12-011010.3389/fchem.2022.10631521063152Application of nanomaterials in diagnosis and treatment of glioblastomaShuangqi Yu0Shuangqi Yu1Lijie Chen2Hongyu Xu3Hongyu Xu4Shengrong Long5Shengrong Long6Jiazhi Jiang7Jiazhi Jiang8Wei Wei9Wei Wei10Xing Niu11Xiang Li12Xiang Li13Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaChina Medical University, Shenyang, Liaoning, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaChina Medical University, Shenyang, Liaoning, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaBrain Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDiagnosing and treating glioblastoma patients is currently hindered by several obstacles, such as tumor heterogeneity, the blood-brain barrier, tumor complexity, drug efflux pumps, and tumor immune escape mechanisms. Combining multiple methods can increase benefits against these challenges. For example, nanomaterials can improve the curative effect of glioblastoma treatments, and the synergistic combination of different drugs can markedly reduce their side effects. In this review, we discuss the progression and main issues regarding glioblastoma diagnosis and treatment, the classification of nanomaterials, and the delivery mechanisms of nanomedicines. We also examine tumor targeting and promising nano-diagnosis or treatment principles based on nanomedicine. We also summarize the progress made on the advanced application of combined nanomaterial-based diagnosis and treatment tools and discuss their clinical prospects. This review aims to provide a better understanding of nano-drug combinations, nano-diagnosis, and treatment options for glioblastoma, as well as insights for developing new tools.https://www.frontiersin.org/articles/10.3389/fchem.2022.1063152/fullglioblastomagliomatumor targetingnanomaterialblood-brain barrier |
| spellingShingle | Shuangqi Yu Shuangqi Yu Lijie Chen Hongyu Xu Hongyu Xu Shengrong Long Shengrong Long Jiazhi Jiang Jiazhi Jiang Wei Wei Wei Wei Xing Niu Xiang Li Xiang Li Application of nanomaterials in diagnosis and treatment of glioblastoma Frontiers in Chemistry glioblastoma glioma tumor targeting nanomaterial blood-brain barrier |
| title | Application of nanomaterials in diagnosis and treatment of glioblastoma |
| title_full | Application of nanomaterials in diagnosis and treatment of glioblastoma |
| title_fullStr | Application of nanomaterials in diagnosis and treatment of glioblastoma |
| title_full_unstemmed | Application of nanomaterials in diagnosis and treatment of glioblastoma |
| title_short | Application of nanomaterials in diagnosis and treatment of glioblastoma |
| title_sort | application of nanomaterials in diagnosis and treatment of glioblastoma |
| topic | glioblastoma glioma tumor targeting nanomaterial blood-brain barrier |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1063152/full |
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