Late-onset megaconial myopathy in mice lacking group I Paks

Late-onset megaconial myopathy in mice lacking group I Paks

Abstract Background Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstrated that Pak1 and Pak2 function redundantly to promote skeletal myobla...

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Bibliographic Details
Main Authors: Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, René L. Jacobs, Robert S. Krauss
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Skeletal Muscle
Subjects:
Pak kinase
Skeletal muscle
Myopathy
Mitochondria
Choline kinase
Online Access:http://link.springer.com/article/10.1186/s13395-019-0191-4

Internet

http://link.springer.com/article/10.1186/s13395-019-0191-4

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