Unveiling the Efficacy of Sesquiterpenes from Marine Sponge <i>Dactylospongia elegans</i> in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge <i>Dactylospongia elegans</i> in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies

Dihydrofolate reductase (DHFR) is a crucial enzyme that maintains the levels of 5,6,7,8-tetrahydrofolate (THF) required for the biological synthesis of the building blocks of DNA, RNA, and proteins. Over-activation of DHFR results in the progression of multiple pathological conditions such as cancer...

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Bibliographic Details
Main Authors: Abdelsattar M. Omar, Khadijah A. Mohammad, Ikhlas A. Sindi, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
dihydrofolate reductase
sesquiterpenes
<i>Dactylospongia elegans</i>
industrial development
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/28/3/1292

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