Mammographic density changes in surgical weight loss-an indication for personalized screening
Abstract Background Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). Methods Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demogra...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Medical Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s12880-017-0242-4 |
| _version_ | 1811231330888843264 |
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| author | Natalia Partain Ali Mokdad Nancy Puzziferri Jessica Porembka Stephen Seiler Alana Christie Deborah Farr Aeisha Rivers A. Marilyn Leitch Rachel Wooldridge James Huth Roshni Rao |
| author_facet | Natalia Partain Ali Mokdad Nancy Puzziferri Jessica Porembka Stephen Seiler Alana Christie Deborah Farr Aeisha Rivers A. Marilyn Leitch Rachel Wooldridge James Huth Roshni Rao |
| author_sort | Natalia Partain |
| collection | DOAJ |
| description | Abstract Background Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). Methods Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories. Results Patients underwent sleeve gastrectomy (n = 56) or gastric bypass (n = 7), 78% had hypertension, 48% had diabetes. Four had deleterious BRCA mutations, four were calculated high risk. Mean weight loss = 28.7 kg. Mean initial BMI = 44.3 kg/m2 (range:33–77), final BMI = 33.6 kg/m2 (range:20–62;p < 0.01). Density was unchanged in 53, decreased in 1, increased in 9. Of these 9(14%), 5 changed from almost entirely fatty to scattered MD, and 4 changed from scattered MD to heterogeneously dense. Mean weight loss of the 9 with increased MD was greater than the cohort (37.7vs.28.7 kg;p < 0.01). Conclusions Surgical weight loss increased MD in 14%. Increased MD masks malignancies, patients may benefit from additional screening based on calculated risk assessments that include MD. |
| first_indexed | 2024-04-12T10:43:20Z |
| format | Article |
| id | doaj.art-31371394e38744f9a95f535ed1665747 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-12T10:43:20Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-31371394e38744f9a95f535ed16657472022-12-22T03:36:31ZengBMCBMC Medical Imaging1471-23422018-05-011811610.1186/s12880-017-0242-4Mammographic density changes in surgical weight loss-an indication for personalized screeningNatalia Partain0Ali Mokdad1Nancy Puzziferri2Jessica Porembka3Stephen Seiler4Alana Christie5Deborah Farr6Aeisha Rivers7A. Marilyn Leitch8Rachel Wooldridge9James Huth10Roshni Rao11Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical CenterDepartment of Radiology, University of Texas Southwestern Medical CenterDepartment of Radiology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDepartment of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical CenterDivision of Breast Surgery, Columbia University Medical Center/New York PresbyterianAbstract Background Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). Methods Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories. Results Patients underwent sleeve gastrectomy (n = 56) or gastric bypass (n = 7), 78% had hypertension, 48% had diabetes. Four had deleterious BRCA mutations, four were calculated high risk. Mean weight loss = 28.7 kg. Mean initial BMI = 44.3 kg/m2 (range:33–77), final BMI = 33.6 kg/m2 (range:20–62;p < 0.01). Density was unchanged in 53, decreased in 1, increased in 9. Of these 9(14%), 5 changed from almost entirely fatty to scattered MD, and 4 changed from scattered MD to heterogeneously dense. Mean weight loss of the 9 with increased MD was greater than the cohort (37.7vs.28.7 kg;p < 0.01). Conclusions Surgical weight loss increased MD in 14%. Increased MD masks malignancies, patients may benefit from additional screening based on calculated risk assessments that include MD.http://link.springer.com/article/10.1186/s12880-017-0242-4Mammographic densityBreast cancerSurgical weight lossBariatric surgery |
| spellingShingle | Natalia Partain Ali Mokdad Nancy Puzziferri Jessica Porembka Stephen Seiler Alana Christie Deborah Farr Aeisha Rivers A. Marilyn Leitch Rachel Wooldridge James Huth Roshni Rao Mammographic density changes in surgical weight loss-an indication for personalized screening BMC Medical Imaging Mammographic density Breast cancer Surgical weight loss Bariatric surgery |
| title | Mammographic density changes in surgical weight loss-an indication for personalized screening |
| title_full | Mammographic density changes in surgical weight loss-an indication for personalized screening |
| title_fullStr | Mammographic density changes in surgical weight loss-an indication for personalized screening |
| title_full_unstemmed | Mammographic density changes in surgical weight loss-an indication for personalized screening |
| title_short | Mammographic density changes in surgical weight loss-an indication for personalized screening |
| title_sort | mammographic density changes in surgical weight loss an indication for personalized screening |
| topic | Mammographic density Breast cancer Surgical weight loss Bariatric surgery |
| url | http://link.springer.com/article/10.1186/s12880-017-0242-4 |
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