Prevalence of celiac disease in healthy Iranian school children
BACKGROUND AND OBJECTIVES: Other than its classic presentation, celiac disease can be completely asymptomatic in a proportion of the general population. Subjects with silent celiac disease are at risk of potential complications of the disease, which indicates the importance of early diagnosis. In th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2013-03-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2013.159 |
| _version_ | 1818695028307918848 |
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| author | Seyed Mohsen Dehghani Mahmood Haghighat Arash Mobayen Abbas Rezaianzadeh Bita Geramizadeh |
| author_facet | Seyed Mohsen Dehghani Mahmood Haghighat Arash Mobayen Abbas Rezaianzadeh Bita Geramizadeh |
| author_sort | Seyed Mohsen Dehghani |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVES: Other than its classic presentation, celiac disease can be completely asymptomatic in a proportion of the general population. Subjects with silent celiac disease are at risk of potential complications of the disease, which indicates the importance of early diagnosis. In this study we investigated the prevalence of silent celiac disease in healthy children in our area. DESIGN AND SETTING: Cross-sectional screening of healthy children in Shiraz city. SUBJECTS AND METHODS: Fifteen hundred school children, 6 to 12 years of age in Shiraz (Southern Iran) were screened for celiac disease through serological testing of their serum anti-tissue transglutaminase immunoglobulin A antibodies. A small intestinal biopsy was performed for children with positive serology tests and pathologic reports were given according to the modified Marsh criteria. RESULTS: Of the total students included, with a mean (SD) age of 9.5 (1.3) years, 30 subjects had positive anti-tissue transglutaminase immunoglobulin A antibodies, resulting in a total seropositivity of 2%. The prevalence of biopsy proven celiac disease (silent celiac) was 0.6%. CONCLUSION: As in many other regions worldwide, this study estimated a relatively high prevalence of silent celiac disease in children in our area, citing the disease as an important health problem in our region. |
| first_indexed | 2024-12-17T13:38:57Z |
| format | Article |
| id | doaj.art-31377f703f6e48a68f658c10d16a61a9 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-17T13:38:57Z |
| publishDate | 2013-03-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-31377f703f6e48a68f658c10d16a61a92022-12-21T21:46:21ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662013-03-0133215916110.5144/0256-4947.2013.159asm-2-159Prevalence of celiac disease in healthy Iranian school childrenSeyed Mohsen Dehghani0Mahmood Haghighat1Arash Mobayen2Abbas Rezaianzadeh3Bita Geramizadeh4From the Shiraz University of Medical Sciences - Gastroenterohepatology Research Center, Shiraz Transplant Research CenterFrom the Shiraz University of Medical Sciences - Gastroenterohepatology Research Center, Shiraz Transplant Research CenterFrom the Shiraz University of Medical Sciences - Gastroenterohepatology Research Center, Shiraz Transplant Research CenterFrom the Shiraz University of Medical Sciences - Gastroenterohepatology Research Center, Shiraz Transplant Research CenterFrom the Shiraz University of Medical Sciences - Gastroenterohepatology Research Center, Shiraz Transplant Research CenterBACKGROUND AND OBJECTIVES: Other than its classic presentation, celiac disease can be completely asymptomatic in a proportion of the general population. Subjects with silent celiac disease are at risk of potential complications of the disease, which indicates the importance of early diagnosis. In this study we investigated the prevalence of silent celiac disease in healthy children in our area. DESIGN AND SETTING: Cross-sectional screening of healthy children in Shiraz city. SUBJECTS AND METHODS: Fifteen hundred school children, 6 to 12 years of age in Shiraz (Southern Iran) were screened for celiac disease through serological testing of their serum anti-tissue transglutaminase immunoglobulin A antibodies. A small intestinal biopsy was performed for children with positive serology tests and pathologic reports were given according to the modified Marsh criteria. RESULTS: Of the total students included, with a mean (SD) age of 9.5 (1.3) years, 30 subjects had positive anti-tissue transglutaminase immunoglobulin A antibodies, resulting in a total seropositivity of 2%. The prevalence of biopsy proven celiac disease (silent celiac) was 0.6%. CONCLUSION: As in many other regions worldwide, this study estimated a relatively high prevalence of silent celiac disease in children in our area, citing the disease as an important health problem in our region.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2013.159 |
| spellingShingle | Seyed Mohsen Dehghani Mahmood Haghighat Arash Mobayen Abbas Rezaianzadeh Bita Geramizadeh Prevalence of celiac disease in healthy Iranian school children Annals of Saudi Medicine |
| title | Prevalence of celiac disease in healthy Iranian school children |
| title_full | Prevalence of celiac disease in healthy Iranian school children |
| title_fullStr | Prevalence of celiac disease in healthy Iranian school children |
| title_full_unstemmed | Prevalence of celiac disease in healthy Iranian school children |
| title_short | Prevalence of celiac disease in healthy Iranian school children |
| title_sort | prevalence of celiac disease in healthy iranian school children |
| url | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2013.159 |
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