Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1

Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1

Porcine circovirus 3 (PCV3) infections cause clinical diseases similar to those seen in porcine circovirus 2 (PCV2) infections. It is unclear whether PCV3 infections can also cause immunosuppression like that seen with PCV2. Here, we report that Cap inhibits DNA-induced IFN-β mRNA transcription and...

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Bibliographic Details
Main Authors: Pengfei Zhang, Hanqin Shen, Xianhui Liu, Shuangyun Wang, Yanling Liu, Zheng Xu, Changxu Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Veterinary Science
Subjects:
porcine circovirus
PCV3
IFN signaling
capsid protein
cGAS
G3BP1
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.594438/full

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