Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Summary: The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) and provide mechanistic insight into the tight regula...

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Bibliographic Details
Main Authors: Matthew Bratkowski, Tian Xie, Desiree A. Thayer, Shradha Lad, Prakhyat Mathur, Yu-San Yang, Gregory Danko, Thomas C. Burdett, Jean Danao, Aaron Cantor, Jennifer A. Kozak, Sean P. Brown, Xiaochen Bai, Shilpa Sambashivan
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
SARM1
axonopathies
axon
NAD hydrolase
autoinhibition
NMN
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309840

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