| Summary: | Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences.
Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients with acne by complex pharmacological correction of its manifestations.
Methods: The study included 110 people (32 men and 78 women) aged from 17 to 35 years, divided into 5 equal groups (according to the type of therapy) and observed for 6 months. All the patients underwent a comprehensive examination, including calculation of the dermatological index of acne (DIA), psychometric tests as well as an immunological study.
Results and discussion: Monotherapy with combined topical agents leads to a decrease in DIA (48.75%) and the length of remission for more than 6 months in 46.4% of observations. Phabomotisol decreased DIA count and improved psychometric parameters. Ionized liquid (IL) led to an increase in CD4 + lymphocytes (14.48%) and immunoregulatory index (40.88%), decreased in the number of CD8 + lymphocytes (17.92%). The most effective combination was phabomotisol and IL (negative redox potential): DIA decreased (74.36%), remission of more than 1 year was observed in 22.7% patients.
Conclusion: Effectiveness therapy with phabomotizol was shown. Effectiveness of IL in the complex treatment of acne in the medium-severe course of the disease is estimated for the first time. Presence of immunotropic properties of IL was established. Possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated.
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