COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE
Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences. Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients wi...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2017-09-01
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| Series: | Research Results in Pharmacology |
| Subjects: | |
| Online Access: | https://rrpharmacology.pensoft.net/article/31099/download/pdf/ |
| _version_ | 1797430381408944128 |
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| author | Olga Samodai Konstantin Reznikov |
| author_facet | Olga Samodai Konstantin Reznikov |
| author_sort | Olga Samodai |
| collection | DOAJ |
| description | Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences.
Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients with acne by complex pharmacological correction of its manifestations.
Methods: The study included 110 people (32 men and 78 women) aged from 17 to 35 years, divided into 5 equal groups (according to the type of therapy) and observed for 6 months. All the patients underwent a comprehensive examination, including calculation of the dermatological index of acne (DIA), psychometric tests as well as an immunological study.
Results and discussion: Monotherapy with combined topical agents leads to a decrease in DIA (48.75%) and the length of remission for more than 6 months in 46.4% of observations. Phabomotisol decreased DIA count and improved psychometric parameters. Ionized liquid (IL) led to an increase in CD4 + lymphocytes (14.48%) and immunoregulatory index (40.88%), decreased in the number of CD8 + lymphocytes (17.92%). The most effective combination was phabomotisol and IL (negative redox potential): DIA decreased (74.36%), remission of more than 1 year was observed in 22.7% patients.
Conclusion: Effectiveness therapy with phabomotizol was shown. Effectiveness of IL in the complex treatment of acne in the medium-severe course of the disease is estimated for the first time. Presence of immunotropic properties of IL was established. Possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated. |
| first_indexed | 2024-03-09T09:26:47Z |
| format | Article |
| id | doaj.art-313c1979c4c5428380b08d1f59cc46ca |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:26:47Z |
| publishDate | 2017-09-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-313c1979c4c5428380b08d1f59cc46ca2023-12-02T05:40:36ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2017-09-01339710910.18413/2313-8971-2017-3-3-97-10931099COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNEOlga SamodaiKonstantin ReznikovIntroduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences. Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients with acne by complex pharmacological correction of its manifestations. Methods: The study included 110 people (32 men and 78 women) aged from 17 to 35 years, divided into 5 equal groups (according to the type of therapy) and observed for 6 months. All the patients underwent a comprehensive examination, including calculation of the dermatological index of acne (DIA), psychometric tests as well as an immunological study. Results and discussion: Monotherapy with combined topical agents leads to a decrease in DIA (48.75%) and the length of remission for more than 6 months in 46.4% of observations. Phabomotisol decreased DIA count and improved psychometric parameters. Ionized liquid (IL) led to an increase in CD4 + lymphocytes (14.48%) and immunoregulatory index (40.88%), decreased in the number of CD8 + lymphocytes (17.92%). The most effective combination was phabomotisol and IL (negative redox potential): DIA decreased (74.36%), remission of more than 1 year was observed in 22.7% patients. Conclusion: Effectiveness therapy with phabomotizol was shown. Effectiveness of IL in the complex treatment of acne in the medium-severe course of the disease is estimated for the first time. Presence of immunotropic properties of IL was established. Possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated.https://rrpharmacology.pensoft.net/article/31099/download/pdf/acneadolescenceadultacne complex therapyps |
| spellingShingle | Olga Samodai Konstantin Reznikov COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE Research Results in Pharmacology acne adolescence adult acne complex therapy ps |
| title | COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE |
| title_full | COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE |
| title_fullStr | COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE |
| title_full_unstemmed | COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE |
| title_short | COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE |
| title_sort | complex correction of psychoemotional and immunological changes in patients with acne |
| topic | acne adolescence adult acne complex therapy ps |
| url | https://rrpharmacology.pensoft.net/article/31099/download/pdf/ |
| work_keys_str_mv | AT olgasamodai complexcorrectionofpsychoemotionalandimmunologicalchangesinpatientswithacne AT konstantinreznikov complexcorrectionofpsychoemotionalandimmunologicalchangesinpatientswithacne |