Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models
The purpose of this paper is to emphasize the need for more complex bone remodeling platforms that allow for investigations of intricate multicellular interactions that regulate this process. We discuss the efforts we have taken to develop lab-on-a-chip systems for bone remodeling and the motivation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2020-01-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2020063?viewType=HTML |
| _version_ | 1818619415435935744 |
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| author | Sharon L. Truesdell Marnie M. Saunders |
| author_facet | Sharon L. Truesdell Marnie M. Saunders |
| author_sort | Sharon L. Truesdell |
| collection | DOAJ |
| description | The purpose of this paper is to emphasize the need for more complex bone remodeling platforms that allow for investigations of intricate multicellular interactions that regulate this process. We discuss the efforts we have taken to develop lab-on-a-chip systems for bone remodeling and the motivation for pursuing more advanced multicellular models. Further, we discuss mathematical modeling opportunities that will allow experimental results to extend beyond the set laboratory conditions. We advocate for the development of an agent-based model comprised of multiple cellular automata of each bone cell type. In total, this work requires a combination of techniques from bone biology, microfluidics, cell mechanobiology, mechanics, and mathematical modeling. Thus, significant advancements within the field will require a collective contribution from a variety of research laboratories. |
| first_indexed | 2024-12-16T17:37:07Z |
| format | Article |
| id | doaj.art-313d9bec569c4584804c873632badd87 |
| institution | Directory Open Access Journal |
| issn | 1551-0018 |
| language | English |
| last_indexed | 2024-12-16T17:37:07Z |
| publishDate | 2020-01-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj.art-313d9bec569c4584804c873632badd872022-12-21T22:22:42ZengAIMS PressMathematical Biosciences and Engineering1551-00182020-01-011721233125210.3934/mbe.2020063Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based modelsSharon L. Truesdell0Marnie M. Saunders1The Bone Biomechanics and Mechanobiology Lab, Department of Biomedical Engineering, The University of Akron, Akron, OH, USAThe Bone Biomechanics and Mechanobiology Lab, Department of Biomedical Engineering, The University of Akron, Akron, OH, USAThe purpose of this paper is to emphasize the need for more complex bone remodeling platforms that allow for investigations of intricate multicellular interactions that regulate this process. We discuss the efforts we have taken to develop lab-on-a-chip systems for bone remodeling and the motivation for pursuing more advanced multicellular models. Further, we discuss mathematical modeling opportunities that will allow experimental results to extend beyond the set laboratory conditions. We advocate for the development of an agent-based model comprised of multiple cellular automata of each bone cell type. In total, this work requires a combination of techniques from bone biology, microfluidics, cell mechanobiology, mechanics, and mathematical modeling. Thus, significant advancements within the field will require a collective contribution from a variety of research laboratories.https://www.aimspress.com/article/doi/10.3934/mbe.2020063?viewType=HTMLbone remodelinglab-on-a-chipagent-based modelscellular automatamechanotransductionconditioned medium |
| spellingShingle | Sharon L. Truesdell Marnie M. Saunders Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models Mathematical Biosciences and Engineering bone remodeling lab-on-a-chip agent-based models cellular automata mechanotransduction conditioned medium |
| title | Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models |
| title_full | Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models |
| title_fullStr | Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models |
| title_full_unstemmed | Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models |
| title_short | Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models |
| title_sort | bone remodeling platforms understanding the need for multicellular lab on a chip systems and predictive agent based models |
| topic | bone remodeling lab-on-a-chip agent-based models cellular automata mechanotransduction conditioned medium |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2020063?viewType=HTML |
| work_keys_str_mv | AT sharonltruesdell boneremodelingplatformsunderstandingtheneedformulticellularlabonachipsystemsandpredictiveagentbasedmodels AT marniemsaunders boneremodelingplatformsunderstandingtheneedformulticellularlabonachipsystemsandpredictiveagentbasedmodels |