Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid
The thyroid represents the most prevalent form of head and neck and endocrine cancer. The present investigation demonstrates the anticancer effects of Lusianthridin against cadmium (Cd)-induced thyroid cancer in rats. Swiss Wistar rats were utilized in this experimental study. Cd was employed to ind...
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024031116 |
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| author | Teng Gao Sijia Luo Hongguang Li Zijie Su Qinghui Wen |
| author_facet | Teng Gao Sijia Luo Hongguang Li Zijie Su Qinghui Wen |
| author_sort | Teng Gao |
| collection | DOAJ |
| description | The thyroid represents the most prevalent form of head and neck and endocrine cancer. The present investigation demonstrates the anticancer effects of Lusianthridin against cadmium (Cd)-induced thyroid cancer in rats. Swiss Wistar rats were utilized in this experimental study. Cd was employed to induce thyroid cancer, and the rats were divided into different groups, receiving oral administration of Lusianthridin (20 mg/kg) for 14 days. Thyroid parameters, deiodinase levels, hepatic parameters, lipid parameters, and antioxidant parameters were respectively estimated. The mRNA expression was assessed using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Lusianthridin significantly (P < 0.001) improved protein levels, T4, T3, free iodine in urine, and suppressed the level of TSH. Lusianthridin significantly (P < 0.001) enhanced the levels of FT3, FT4, and decreased the level of rT3. Lusianthridin significantly (P < 0.001) reduced the levels of D1, D2, D3, and enhanced the levels of hepatic parameters like AST, ALT. Lusianthridin remarkably (P < 0.001) altered the levels of lipid parameters such as LDL, total cholesterol, HDL, and triglycerides; antioxidant parameters viz., MDA, GSH, CAT, and SOD. Lusianthridin significantly altered the mRNA expression of Bcl-2, Bax, MEK1, ERK1, ERK2, p-eIf2α, GRP78, eIf2α, and GRP94. The results clearly state that Lusianthridin exhibits protective effects against thyroid cancer. |
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| id | doaj.art-313e6efaf9284ae983fc86a33518b415 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:14:46Z |
| publishDate | 2024-03-01 |
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| series | Heliyon |
| spelling | doaj.art-313e6efaf9284ae983fc86a33518b4152024-03-17T07:57:16ZengElsevierHeliyon2405-84402024-03-01105e27080Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroidTeng Gao0Sijia Luo1Hongguang Li2Zijie Su3Qinghui Wen4Department of Thyroid Surgery, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, 450003, ChinaDepartment of General Surgery, General Hospital of Central Theater Command, Wuhan, Hubei, 430070, ChinaDepartment of Thyroid Surgery, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, 450003, ChinaDepartment of Thyroid Surgery, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, 450003, ChinaDepartment of Clinical Laboratory, Dongguan People's Hospital, Dongguan, Guangdong, 523059, China; Corresponding author.The thyroid represents the most prevalent form of head and neck and endocrine cancer. The present investigation demonstrates the anticancer effects of Lusianthridin against cadmium (Cd)-induced thyroid cancer in rats. Swiss Wistar rats were utilized in this experimental study. Cd was employed to induce thyroid cancer, and the rats were divided into different groups, receiving oral administration of Lusianthridin (20 mg/kg) for 14 days. Thyroid parameters, deiodinase levels, hepatic parameters, lipid parameters, and antioxidant parameters were respectively estimated. The mRNA expression was assessed using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Lusianthridin significantly (P < 0.001) improved protein levels, T4, T3, free iodine in urine, and suppressed the level of TSH. Lusianthridin significantly (P < 0.001) enhanced the levels of FT3, FT4, and decreased the level of rT3. Lusianthridin significantly (P < 0.001) reduced the levels of D1, D2, D3, and enhanced the levels of hepatic parameters like AST, ALT. Lusianthridin remarkably (P < 0.001) altered the levels of lipid parameters such as LDL, total cholesterol, HDL, and triglycerides; antioxidant parameters viz., MDA, GSH, CAT, and SOD. Lusianthridin significantly altered the mRNA expression of Bcl-2, Bax, MEK1, ERK1, ERK2, p-eIf2α, GRP78, eIf2α, and GRP94. The results clearly state that Lusianthridin exhibits protective effects against thyroid cancer.http://www.sciencedirect.com/science/article/pii/S2405844024031116LusianthridinDeiodinaseLipidAntioxidantmRNA |
| spellingShingle | Teng Gao Sijia Luo Hongguang Li Zijie Su Qinghui Wen Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid Heliyon Lusianthridin Deiodinase Lipid Antioxidant mRNA |
| title | Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid |
| title_full | Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid |
| title_fullStr | Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid |
| title_full_unstemmed | Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid |
| title_short | Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid |
| title_sort | prospective role of lusianthridin in attenuating cadmium induced functional and cellular damage in rat thyroid |
| topic | Lusianthridin Deiodinase Lipid Antioxidant mRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024031116 |
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