The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER

The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER

Summary: Tail-anchored (TA) proteins contain a single C-terminal transmembrane domain (TMD) that is captured by the cytosolic Get3 in yeast (TRC40 in humans). Get3 delivers TA proteins to the Get1/2 complex for insertion into the endoplasmic reticulum (ER) membrane. How Get1/2 mediates insertion of...

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Bibliographic Details
Main Authors: Paul Heo, Jacob A. Culver, Jennifer Miao, Frederic Pincet, Malaiyalam Mariappan
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722018198

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