Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
Abstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-06214-y |
| _version_ | 1818405527811522560 |
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| author | S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf |
| author_facet | S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf |
| author_sort | S. Hong Lee |
| collection | DOAJ |
| description | Abstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions. |
| first_indexed | 2024-12-14T08:57:28Z |
| format | Article |
| id | doaj.art-31422cd757134332a89b106443c2196e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:57:28Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-31422cd757134332a89b106443c2196e2022-12-21T23:08:53ZengNature PortfolioScientific Reports2045-23222017-07-017111210.1038/s41598-017-06214-yGenotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birthS. Hong Lee0W. M. Shalanee P. Weerasinghe1Julius H. J. van der Werf2School of Environmental and Rural Science, University of New EnglandSchool of Environmental and Rural Science, University of New EnglandSchool of Environmental and Rural Science, University of New EnglandAbstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions.https://doi.org/10.1038/s41598-017-06214-y |
| spellingShingle | S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth Scientific Reports |
| title | Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| title_full | Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| title_fullStr | Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| title_full_unstemmed | Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| title_short | Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| title_sort | genotype environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth |
| url | https://doi.org/10.1038/s41598-017-06214-y |
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