The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

Reprogramming of cellular metabolism plays a central role in fueling malignant transformation, and AMPK and the PGC-1α/ERRα axis are key regulators of this process. The intersection of gene-expression and binding-event datasets for breast cancer cells shows that activation of AMPK significantly incr...

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Bibliographic Details
Main Authors: Étienne Audet-Walsh, David J. Papadopoli, Simon-Pierre Gravel, Tracey Yee, Gaëlle Bridon, Maxime Caron, Guillaume Bourque, Vincent Giguère, Julie St-Pierre
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Subjects:
AMPK
folate
metabolic reprogramming
methotrexate
nuclear receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015429

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