Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients
Background: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-07-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753466618787385 |
| _version_ | 1819100092224765952 |
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| author | Luis Máiz Rosa M. Girón Eva Prats Marta G. Clemente Eva Polverino Silvia Caño Rosa Cordovilla Jordi Dorca Carlos Peñalver Félix Baranda Miguel A. Martínez-García |
| author_facet | Luis Máiz Rosa M. Girón Eva Prats Marta G. Clemente Eva Polverino Silvia Caño Rosa Cordovilla Jordi Dorca Carlos Peñalver Félix Baranda Miguel A. Martínez-García |
| author_sort | Luis Máiz |
| collection | DOAJ |
| description | Background: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addition of 0.1% hyaluronic acid to HS (HS+HA) could increase tolerance to HS in these patients. The main objective of this study was to evaluate the tolerability of HS+HA in bronchiectasis patients who are intolerant to HS. Methods: This prospective, observational, open-label study analysed the outcomes of two groups of bronchiectasis patients previously scheduled to start HS therapy. Patients were assessed for tolerance to HS by a questionnaire, spirometry and clinical evaluation. Patients who were intolerant were evaluated for tolerance to HS+HA approximately one week later. All patients were evaluated for their tolerance to HS or HS+HA 4 weeks after the start of their treatment. Patients were also assessed with quality-of-life and adherence questionnaires, and all adverse events were registered. Results: A total of 137 bronchiectasis patients were enrolled in the study (age = 63.0 ± 14.7 years; 63.5% women). Of these, 92 patients (67.1%) were tolerant and 45 patients (32.9%) were intolerant to HS. Of the 45 patients intolerant to HS, 31 patients (68.9%) were tolerant and 14 patients (31.1%) intolerant to HS+HA. Of these 31 tolerant patients, 26 (83.9%) could complete the 4-week treatment with HS+HA. Conclusions: Two-thirds of bronchiectasis patients that presented intolerance to inhaled HS alone are tolerant to inhaled HS+HA, suggesting that HA improves tolerance to HS therapy. |
| first_indexed | 2024-12-22T00:57:16Z |
| format | Article |
| id | doaj.art-3148296e76604b9f87eae3a9ae89fc80 |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-12-22T00:57:16Z |
| publishDate | 2018-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-3148296e76604b9f87eae3a9ae89fc802022-12-21T18:44:16ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662018-07-011210.1177/1753466618787385Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patientsLuis MáizRosa M. GirónEva PratsMarta G. ClementeEva PolverinoSilvia CañoRosa CordovillaJordi DorcaCarlos PeñalverFélix BarandaMiguel A. Martínez-GarcíaBackground: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addition of 0.1% hyaluronic acid to HS (HS+HA) could increase tolerance to HS in these patients. The main objective of this study was to evaluate the tolerability of HS+HA in bronchiectasis patients who are intolerant to HS. Methods: This prospective, observational, open-label study analysed the outcomes of two groups of bronchiectasis patients previously scheduled to start HS therapy. Patients were assessed for tolerance to HS by a questionnaire, spirometry and clinical evaluation. Patients who were intolerant were evaluated for tolerance to HS+HA approximately one week later. All patients were evaluated for their tolerance to HS or HS+HA 4 weeks after the start of their treatment. Patients were also assessed with quality-of-life and adherence questionnaires, and all adverse events were registered. Results: A total of 137 bronchiectasis patients were enrolled in the study (age = 63.0 ± 14.7 years; 63.5% women). Of these, 92 patients (67.1%) were tolerant and 45 patients (32.9%) were intolerant to HS. Of the 45 patients intolerant to HS, 31 patients (68.9%) were tolerant and 14 patients (31.1%) intolerant to HS+HA. Of these 31 tolerant patients, 26 (83.9%) could complete the 4-week treatment with HS+HA. Conclusions: Two-thirds of bronchiectasis patients that presented intolerance to inhaled HS alone are tolerant to inhaled HS+HA, suggesting that HA improves tolerance to HS therapy.https://doi.org/10.1177/1753466618787385 |
| spellingShingle | Luis Máiz Rosa M. Girón Eva Prats Marta G. Clemente Eva Polverino Silvia Caño Rosa Cordovilla Jordi Dorca Carlos Peñalver Félix Baranda Miguel A. Martínez-García Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients Therapeutic Advances in Respiratory Disease |
| title | Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients |
| title_full | Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients |
| title_fullStr | Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients |
| title_full_unstemmed | Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients |
| title_short | Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients |
| title_sort | addition of hyaluronic acid improves tolerance to 7 hypertonic saline solution in bronchiectasis patients |
| url | https://doi.org/10.1177/1753466618787385 |
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