Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina
Abstract Background Left ventricular (LV) diastolic dysfunction occurs earlier in the ischemic cascade than LV systolic dysfunction and electrocardiographic changes. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to d...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0739-3 |
| _version_ | 1819297880922390528 |
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| author | Jaehuk Choi Min-Kyung Kang Chaehoon Han Sang Muk Hwang Sung Gu Jung Han-Kyul Kim Kwang Jin Chun Seonghoon Choi Jung Rae Cho Namho Lee |
| author_facet | Jaehuk Choi Min-Kyung Kang Chaehoon Han Sang Muk Hwang Sung Gu Jung Han-Kyul Kim Kwang Jin Chun Seonghoon Choi Jung Rae Cho Namho Lee |
| author_sort | Jaehuk Choi |
| collection | DOAJ |
| description | Abstract Background Left ventricular (LV) diastolic dysfunction occurs earlier in the ischemic cascade than LV systolic dysfunction and electrocardiographic changes. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to define the relationship between DWS and coronary revascularization and to evaluate other echocardiographic parameters in patients with stable angina who were undergoing coronary angiography (CAG). Methods Four hundred forty patients [mean age: 61 ± 10; 249 (57%) men] undergoing CAG and with normal left ventricular systolic function without regional wall motion abnormalities were enrolled. Among them, 128 (29%) patients underwent revascularization (percutaneous intervention: 117, bypass surgery: 11). All patients underwent echocardiography before CAG and the DWS was defined using posterior wall thickness (PWT) measurements from standard echocardiographic images [DWS = PWT(systole)-PWT(diastole)/PWT(systole)]. Results Patients who underwent revascularization had a significantly lower DWS than those who did not (0.26 ± 0.08 vs. 0.38 ± 0.09, p < 0.001). Age was comparable between the two groups (61 ± 9 vs. 60 ± 11, p = 0.337), but the proportion of males was significantly higher among patients who underwent revascularization (69 vs. 52%, p = 0.001). The LV ejection fraction was similar but slightly decreased (60.9 ± 5.7 vs. 62.4 ± 6.2%, p = 0.019) and the E/E’ ratio was elevated (10.3 ± 4.0 vs. 9.0 ± 3.1, p < 0.001) among patients who underwent revascularization. In multiple regression analysis, lower DWS was an independent predictor of revascularization (cut-off value: 0.34; sensitivity: 89%; AUC: 0.870; SE: 0.025; p < 0.001). Conclusion DWS, a simple parameter that can be calculated from routine 2D echocardiography, is inversely associated with the presence of coronary artery disease and the need for revascularization. |
| first_indexed | 2024-12-24T05:21:02Z |
| format | Article |
| id | doaj.art-3149027a97a54b49bb22d09d2660bcb8 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-24T05:21:02Z |
| publishDate | 2017-12-01 |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-3149027a97a54b49bb22d09d2660bcb82022-12-21T17:13:27ZengBMCBMC Cardiovascular Disorders1471-22612017-12-011711810.1186/s12872-017-0739-3Lower diastolic wall strain is associated with coronary revascularization in patients with stable anginaJaehuk Choi0Min-Kyung Kang1Chaehoon Han2Sang Muk Hwang3Sung Gu Jung4Han-Kyul Kim5Kwang Jin Chun6Seonghoon Choi7Jung Rae Cho8Namho Lee9Division of Cardiology, Hangang Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterCardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical CenterAbstract Background Left ventricular (LV) diastolic dysfunction occurs earlier in the ischemic cascade than LV systolic dysfunction and electrocardiographic changes. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to define the relationship between DWS and coronary revascularization and to evaluate other echocardiographic parameters in patients with stable angina who were undergoing coronary angiography (CAG). Methods Four hundred forty patients [mean age: 61 ± 10; 249 (57%) men] undergoing CAG and with normal left ventricular systolic function without regional wall motion abnormalities were enrolled. Among them, 128 (29%) patients underwent revascularization (percutaneous intervention: 117, bypass surgery: 11). All patients underwent echocardiography before CAG and the DWS was defined using posterior wall thickness (PWT) measurements from standard echocardiographic images [DWS = PWT(systole)-PWT(diastole)/PWT(systole)]. Results Patients who underwent revascularization had a significantly lower DWS than those who did not (0.26 ± 0.08 vs. 0.38 ± 0.09, p < 0.001). Age was comparable between the two groups (61 ± 9 vs. 60 ± 11, p = 0.337), but the proportion of males was significantly higher among patients who underwent revascularization (69 vs. 52%, p = 0.001). The LV ejection fraction was similar but slightly decreased (60.9 ± 5.7 vs. 62.4 ± 6.2%, p = 0.019) and the E/E’ ratio was elevated (10.3 ± 4.0 vs. 9.0 ± 3.1, p < 0.001) among patients who underwent revascularization. In multiple regression analysis, lower DWS was an independent predictor of revascularization (cut-off value: 0.34; sensitivity: 89%; AUC: 0.870; SE: 0.025; p < 0.001). Conclusion DWS, a simple parameter that can be calculated from routine 2D echocardiography, is inversely associated with the presence of coronary artery disease and the need for revascularization.http://link.springer.com/article/10.1186/s12872-017-0739-3EchocardiographyDiastolic wall strainCoronary revascularization |
| spellingShingle | Jaehuk Choi Min-Kyung Kang Chaehoon Han Sang Muk Hwang Sung Gu Jung Han-Kyul Kim Kwang Jin Chun Seonghoon Choi Jung Rae Cho Namho Lee Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina BMC Cardiovascular Disorders Echocardiography Diastolic wall strain Coronary revascularization |
| title | Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| title_full | Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| title_fullStr | Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| title_full_unstemmed | Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| title_short | Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| title_sort | lower diastolic wall strain is associated with coronary revascularization in patients with stable angina |
| topic | Echocardiography Diastolic wall strain Coronary revascularization |
| url | http://link.springer.com/article/10.1186/s12872-017-0739-3 |
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