Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism
Mineralized collagen scaffold is one of the best choices for bone defects treatment, but weak mechanical strength is the main factor restricting its development. Recent studies demonstrated that despite being a fundamental form of mechanical stimulation in human activities, the impact of cyclic comp...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524002028 |
| _version_ | 1827313717371469824 |
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| author | Yumiao Niu Jiawen Chen Ziyao Geng Wei Wu Hefang Cai Chenxin Liu Peng Cao Yanping Zhang Youjun Liu Aike Qiao Tianming Du |
| author_facet | Yumiao Niu Jiawen Chen Ziyao Geng Wei Wu Hefang Cai Chenxin Liu Peng Cao Yanping Zhang Youjun Liu Aike Qiao Tianming Du |
| author_sort | Yumiao Niu |
| collection | DOAJ |
| description | Mineralized collagen scaffold is one of the best choices for bone defects treatment, but weak mechanical strength is the main factor restricting its development. Recent studies demonstrated that despite being a fundamental form of mechanical stimulation in human activities, the impact of cyclic compressive stress on collagen mineralization remains unclear, with even less known about the dynamic mechanical mechanism. This study employed cyclic compressive stress to investigate its effect on collagen mineralization. The findings revealed that cyclic compressive strain promotes collagen mineralization by facilitating increased mineral penetration into the collagen and altering mineral morphology on the collagen surface. As the mineral volume fraction of mineralized collagen rises, its elastic modulus also increases. Additionally, the finite element simulation results proved that cyclic compressive stress can impact mineral distribution by affecting their transport and deposition, consequently influencing the stress distribution and regulating mechanical properties of mineralized collagen. Alterations in mechanical properties provide feedback on internal stress distribution, subsequently impacting mineral mineralization. This study achieves a closed-loop study on the mechanical regulated collagen mineralization, offers insight into the mechanism of collagen mineralization, paving the way for further exploration of biomineralization mechanisms and potentially inspiring novel approaches for the fabrication of mineralized collagen scaffolds. |
| first_indexed | 2024-04-24T22:21:09Z |
| format | Article |
| id | doaj.art-314aaf0546544375a91ed481a9f21cd9 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-24T22:21:09Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-314aaf0546544375a91ed481a9f21cd92024-03-20T06:08:29ZengElsevierMaterials & Design0264-12752024-03-01239112830Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanismYumiao Niu0Jiawen Chen1Ziyao Geng2Wei Wu3Hefang Cai4Chenxin Liu5Peng Cao6Yanping Zhang7Youjun Liu8Aike Qiao9Tianming Du10Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaBeijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaCorresponding authors at: College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, China.; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaCorresponding authors at: College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, China.; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, ChinaMineralized collagen scaffold is one of the best choices for bone defects treatment, but weak mechanical strength is the main factor restricting its development. Recent studies demonstrated that despite being a fundamental form of mechanical stimulation in human activities, the impact of cyclic compressive stress on collagen mineralization remains unclear, with even less known about the dynamic mechanical mechanism. This study employed cyclic compressive stress to investigate its effect on collagen mineralization. The findings revealed that cyclic compressive strain promotes collagen mineralization by facilitating increased mineral penetration into the collagen and altering mineral morphology on the collagen surface. As the mineral volume fraction of mineralized collagen rises, its elastic modulus also increases. Additionally, the finite element simulation results proved that cyclic compressive stress can impact mineral distribution by affecting their transport and deposition, consequently influencing the stress distribution and regulating mechanical properties of mineralized collagen. Alterations in mechanical properties provide feedback on internal stress distribution, subsequently impacting mineral mineralization. This study achieves a closed-loop study on the mechanical regulated collagen mineralization, offers insight into the mechanism of collagen mineralization, paving the way for further exploration of biomineralization mechanisms and potentially inspiring novel approaches for the fabrication of mineralized collagen scaffolds.http://www.sciencedirect.com/science/article/pii/S0264127524002028BiomineralizationMechano-regulatoryMultiscale modellingMulti-morphologyMechanical propertyStress distribution |
| spellingShingle | Yumiao Niu Jiawen Chen Ziyao Geng Wei Wu Hefang Cai Chenxin Liu Peng Cao Yanping Zhang Youjun Liu Aike Qiao Tianming Du Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism Materials & Design Biomineralization Mechano-regulatory Multiscale modelling Multi-morphology Mechanical property Stress distribution |
| title | Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism |
| title_full | Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism |
| title_fullStr | Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism |
| title_full_unstemmed | Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism |
| title_short | Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism |
| title_sort | compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization a closed loop regulation mechanism |
| topic | Biomineralization Mechano-regulatory Multiscale modelling Multi-morphology Mechanical property Stress distribution |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524002028 |
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